[Skip to Content]
[Skip to Content Landing]
Article
June 1951

VITAMIN A DEFICIENCY WITH CUTANEOUS, CONJUNCTIVAL ("BITOT" SPOTS) AND RENAL MANIFESTATIONS: Report of a Case

Author Affiliations

LOS ANGELES

From the Department of Dermatology and Syphilology, University of Texas, Galveston.

AMA Arch Derm Syphilol. 1951;63(6):759-763. doi:10.1001/archderm.1951.01570060087008
Abstract

IN RECENT years there has been interest in the lesions of the skin associated with vitamin A deficiency. Since Frazier and Hu first reported the syndrome in 19311 and subsequently investigated the cutaneous variations from infancy to puberty among Chinese children, there have been numerous studies from different countries, including our own.

The following case is being reported because, in addition to the interesting cutaneous lesions in a child, it presents accompanying ocular and renal manifestations of the vitamin A deficiency state. A search of the literature indicates that the circumscribed areas of xerosis of the conjunctiva (``Bitot'' spots) and the metabolic calcinoses of both kidneys which were present in this child in combination with the skin lesions of avitaminosis A have not hitherto been described in the United States.

REPORT OF CASE 

History.—  F. L. D., a 10 year old white girl, was admitted to the John Sealy

References
1.
Frazier, C. N., and Hu, C. K.:  Cutaneous Lesions Associated with Deficiency in Vitamin A in Man ,  Arch. Int. Med. 48:507-514 ( (Sept.) ) 1931.Crossref
2.
Veghelyi, P.:  Giardiasis in Children ,  Am. J. Dis. Child. 56: 1231-1241 ( (Dec.) ) 1938;
3.
 Giardiasis , Veghelyi Am. J. Dis. Child. 59:793-804 ( (April) ) 1940.
4.
Frazier, C. N.; Hu, C. K., and Chu, F. T.:  Variations in Cutaneous Manifestations of Vitamin A Deficiency from Infancy to Puberty ,  Arch. Dermat. & Syph. 48:1-14 ( (July) ) 1943.
5.
Bitot, C.:  Mémoire sur une lésion conjonctivale, non encore décrite, coincidant avec l'héméralopie ,  Gaz. hebd. de méd. et de chir. 10:284-288 ( (May 1) ) 1863.
6.
Wolbach, S. B., and Howe, P. R.:  Tissue Changes Following Deprivation of FatSoluble A Vitamin ,  J. Exper. Med. 42:753-777 ( (Dec.) ) 1925.
7.
Bessey, O. A., and Wolbach, S. B.:  Vitamin A: Physiology and Pathology ,  J. A. M. A. 110:2072-2080 ( (June 18) ) 1938.
8.
Boyd, W.:  Text-Book of Pathology: An Introduction to Medicine , ed. 4, Philadelphia, Lea & Febiger, 1943, p. 630.
×