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November 1951

CONGENITAL ICHTHYOSIFORM ERYTHRODERMA: A Report of Two Cases in Siblings, One Complicated by Kaposi's Varicelliform Eruption

Author Affiliations


From the Department of Dermatology and Syphilology and the Department of Pediatrics, University of Virginia Department of Medicine and University of Virginia Hospital.

AMA Arch Derm Syphilol. 1951;64(5):611-619. doi:10.1001/archderm.1951.01570110081012

TWO CHILDREN in the same family with congenital ichthyosiform erythroderma have recently been available for detailed study. This condition is not seen often, and little information on the subject has been published in the current medical literature. In addition, one patient had what is thought to be the first recorded occurrence of Kaposi's varicelliform eruption as a complication of this disease, and his case is one of the few on record with complete autopsy findings.

Congenital ichthyosiform erythroderma was described by Brocq1 in 1902, although it had been recognized as a clinical entity by Vidal2 in 1882. However, according to Bruhns,3 the first case was reported by Sangster in 1895. Important reviews of the literature were made by MacKee and Rosen4 in 1917 and by Weiss and Tobias5 in 1925. Laymon and Murphy6 in 1948 presented a detailed report of the clinical features, histological

Brocq, L.:  Érythrodermie congénitale ichthyosiforme avec hyperepidermotrophie ,  Ann. dermat. et syph. 3:1, 1902.
Vidal, cited by Laymon, C. W., and Murphy, R.:  Congenital Ichthyosiform Erythroderma ,  Arch. Dermat. & Syph. 57:615 ( (April) ) 1948.
Bruhns, C.: Ichthyosis, in Jadassohn, J.:  Handbuch der Haut- und Geschlechtskrankheiten , Berlin, Julius Springer, 1931, Vol. 8, Pt. (2) , pp. 1-52.
MacKee, G. M., and Rosen, I.:  Erythrodermie congénitale ichthyosiforme ,  J. Cutan. Dis. 35:235 ( (April) ), 343 (May-June), and 511 (Aug.) 1917.
Weiss, R. S., and Tobias, N.:  Congenital Ichthyosiform Erythroderma ,  Arch. Dermat. & Syph. 12:182 ( (Aug.) ) 1925.
Laymon, C. W., and Murphy, R.:  Congenital Ichthyosiform Erythroderma ,  Arch. Dermat. & Syph. 57:615 ( (April) ) 1948.
Wile, U. J.:  Familial Study of 3 Unusual Cases of Congenital Ichthyosiform Erythroderma ,  Arch. Dermat. & Syph. 10:487 ( (Oct.) ) 1924.
Kaposi, M.:  Pathology and Treatment of Diseases of the Skin, for Practitioners and Students , New York, William Wood & Company, 1895, p. 346.
Lynch, F. W., and Steves. R. J.:  Kaposi's Varicelliform Eruption ,  Arch. Dermat. & Syph. 55:327 ( (March) ) 1947.
Fries, J. H.; Borne, S., and Barnes, H. L.:  Varicelliform Eruption of Kaposi Due to Vaccinia Virus Complicating Atopic Eczema ,  J. Pediat. 32:532 ( (May) ) 1948.
Ruchman, I., and Dodd, K.:  Kaposi's Varicelliform Eruption: A Primary Infection with Herpes Simplex Virus ,  Pediatrics 1:364 ( (March) ) 1948.