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Article
January 1955

HYDROCORTISONE (COMPOUND F) FREE ALCOHOL AND HYDROCORTISONE ACETATE FOR TOPICAL USE: A Clinical Evaluation

Author Affiliations

BROOKLYN; QUEENS, N. Y.; BROOKLYN

From the Department of Dermatology and Syphilology, State University of New York College of Medicine at New York City.

AMA Arch Derm. 1955;71(1):117-120. doi:10.1001/archderm.1955.01540250119024
Abstract

The following clinical study was done to compare the effects of hydrocortisone free alcohol and hydrocortisone acetate as topical medicaments and to evaluate the most practical concentration for topical therapy. Although cortisone differs from hydrocortisone in only structural details—there is a ketone group at the C-11 position in the steroid nucleus in place of a hydroxyl radical—cortisone has been found to be rather ineffective topically1 in suppressing inflammatory reaction in the skin. On the other hand, hydrocortisone, which is believed to be the principal hormone secreted by the adrenal cortex,2 is effective.3 The superior effect of hydrocortisone

References
1.
Goldman, L.; Thompson, R. G., and Trice, E. R.:  Cortisone Acetate in Skin Disease: Local Effect in the Skin from Topical Application and Local Injection ,  A. M. A. Arch. Dermat. & Syph. 65:177-186 ( (Feb.) ) 1952.
2.
Thorn, G. W., and others:  Pharmacologic Aspects of Adrenocortical Steroids and ACTH in Man ,  New England J. Med. 248:414-422 ( (March 5) ) 1953.
3.
Sulzberger, M. B., and Witten, V. H.:  Hydrocortisone (Compound F) Acetate Ointment in Dermatological Therapy ,  J. A. M. A. 151:468-472 ( (Feb. 7) ) 1953.
4.
Boland, E. W.:  Clinical Use of Cortisone, Hydrocortisone, and Corticotropin ,  J. A. M. A. 150:1281-1288 ( (Nov. 29) ) 1952.
5.
Sulzberger, M.; Witten, V. H., and Smith, C. C.:  Hydrocortisone (Compound F) Free Alcohol Ointment, Correspondence ,  J. A. M. A. 152: 1456 ( (Aug. 8) ) 1953.
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