Study of the TPI Test in Clinical Syphilis: III. Late Syphilis | JAMA Dermatology | JAMA Network
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March 1955

Study of the TPI Test in Clinical Syphilis: III. Late Syphilis

Author Affiliations

Chamblee, Ga.; New Orleans; Chicago

AMA Arch Derm. 1955;71(3):387-390. doi:10.1001/archderm.1955.01540270099017

In previous publications it has been reported that the Treponema pallidum immobilization (TPI) test may be expected to be reactive in untreated or treated late syphilis.* This study of seroreactivity in patients having untreated and treated late syphilis was undertaken to compare the sensitivity in late syphilis of the TPI test, as modified by Portnoy, Harris, and Olansky, with other serologic tests for syphilis, e. g., Kahn quantitative, Kolmer (cardiolipin) quantitative, and VDRL slide flocculation test quantitative.


One hundred and twenty patients having untreated or treated late syphilis were selected from inpatients and outpatients attendant at the Delgado Outpatient Clinic, New Orleans; Board of Health venereal disease clinic, Chicago; Mayo Clinic, Rochester, Minn.; and Macon County Health Department, Tuskegee, Ala. In all patients, spinal fluid examinations had been performed at some time, and serologic tests for syphilis were performed at

References 1 to 5.
Supplied by Becton-Dickinson Company, Rutherford, N. J.
Gumma of naso-oral cavity in three patients; of the liver in one patient.
Magnuson, H. J., and Thompson, F. A., Jr.:   Treponemal Immobilization Test of Normal and Syphilitic Serums ,  J. Ven. Dis. Inform. 30:309-320 ( (Nov.) ) 1949.
Nelson, R. A., Jr.; Zheutlin, H. E. C.; Diesendruck, J. A., and Austin, P. G. M., Jr.:  Studies on Treponemal Immobilizing Antibodies in Syphilis: II. Incidence in Serum and Cerebrospinal Fluid in Human Beings and Absence in "Biologic False Positive" Reactors ,  Am. J. Syph. 34:101-121 ( (March) ) 1950.
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Nelson, R. A., Jr., and Mayer, M. M.:  Immobilization of Treponema Pallidum in Vitro by Antibody Produced in Syphilitic Infection ,  J. Exper. Med. 89:369-393 ( (April 1) ) 1949.Crossref
Portnoy, J.; Harris, A., and Olansky, S.:  Studies of the Treponema Pallidum Immobilization (TPI) Test: I. The Effect of Increased Sodium Thioglycollate and Complement ,  Am. J. Syph. 37:101-105 ( (March) ) 1953.
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