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Dermatologists daily see evidence seeming to show that distant sites on the skin, if not the general integument, come under the influence of some local involvement. The tendency to so-called "ids," as from a leg ulcer, appears to be such an effect. Various theories to explain such phenomena have been offered, but none has been accepted. Some of the available evidence is in favor of an explanation by allergy and hypersensitization. Another possibility takes into consideration alterations in electrolyte patterns of sodium, potassium, calcium, and magnesium. Still another involves changes in enzyme reactions. Probably more than one cause will finally be found for these associated changes at distant parts of the skin stemming from some local one.
In our program of investigation of some of the electrical characteristics and properties of the skin we turned our attention to the spread of changes in electric potentials
CORNBLEET T, JOSEPH NR. Spread of Redox Potentials over the Skin. AMA Arch Derm. 1955;71(6):731–735. doi:10.1001/archderm.1955.01540300053015
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