[Skip to Content]
[Skip to Content Landing]
Article
August 1955

Pigmented Nevi: A Clinical Appraisal in the Light of Present-Day Histopathologic Concepts

Author Affiliations

Philadelphia

From the Departments of Dermatology of the University of Pennsylvania, Medical School, Dr. Donald M. Pillsbury, Chairman, and Graduate School of Medicine, Dr. Herman Beerman, Chairman, and the Combined Departments of Dermatology, Albert Einstein Medical Center.

AMA Arch Derm. 1955;72(2):120-132. doi:10.1001/archderm.1955.03730320022003
Abstract

Much has been learned in the last two decades about the nature, origin and development of the pigmented nevus.* This has been attained through investigations in comparative embryology, tinctorial histologic studies, and chemical investigations on the nature and elaboration of melanin. However, in spite of this new knowledge there is much uncertainty regarding the clinical pictures associated with the different developmental stages of nevi. This paper is an attempt to relate the clinical types with the different histologic pictures.

The need for more clinical knowledge in this field is self-evident. It would enable the clinician to select for complete surgical removal those lesions which in the opinion of most histologists are presumed to have malignant potentialities. In addition, it would provide the physician with criteria for the use of more convenient and sometimes less cosmetically objectionable methods of treatment, such as, for instance, partial

References
1.
References 1 to 4.
2.
Traub, E. F., and Keil, H.:  The "Common Mole": Its Clinicopathologic Relations and the Question of Malignant Degeneration ,  Arch. Dermat. & Syph. 41:214-249 ( (Feb.) ) 1940.
3.
Becker, S. W.:  Melanin Pigmentation Through the Ages, with Special Reference to Pigmentation of Planarias and Whales, and the Histology of Whale Skin ,  J. Invest. Dermat. 7:381-399 ( (Dec.) ) 1946.
4.
Masson, P.:  My Conception of Cellular Nevi ,  Cancer 4:9-38 ( (Jan.) ) 1951.
5.
Lerner, A. B., and Fitzpatrick, T. B.:  Biochemistry of Melanin Formation ,  Physiol. Rev. 30:91-126 ( (Jan.) ) 1950.
6.
Lund, H. Z., and Stobbe, G. D.:  The Natural History of the Pigmented Nevus: Factors of Age and Anatomic Location ,  Am. J. Path. 25:1117-1155 ( (Nov.) ) 1949.
7.
Allen, A. C., and Spitz, S.:  Malignant Melanoma, a Clinicopathological Analysis of the Criteria for Diagnosis and Prognosis ,  Cancer 6: 1-45 ( (Jan.) ) 1953.
8.
Beerman, H.; Lane, R. A. G., and Shaffer, B.:  Pigmented Nevi and Malignant Melanoma ,  Am. J. M. Sc. , to be published.
9.
Stegmaier, I. C., Jr., and Montgomery, H.:  Histopathologic Studies of Pigmented Nevi in Children ,  J. Invest. Dermat. 20:51-64 ( (Jan.) ) 1953.
×