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September 1955

Studies in Eczematous Sensitizations: V. The Role of the Regional Lymph Node

Author Affiliations


From the Department of Dermatology and the Allergy Unit (Dr. Rostenberg) and the Department of Medicine (Dr. Best), University of Illinois College of Medicine.

AMA Arch Derm. 1955;72(3):221-228. doi:10.1001/archderm.1955.03730330001001


It has been reasonably well shown that the regional lymph node plays an important role in the development of certain types of antibodies. The work of McMaster and Hudack1 and of Ehrich, Harris and their colleagues2 clearly indicates that antibody is made, at least in part, in the regional node, i. e., the node adjacent to the site of introduction of the antigen, and it is probably made there prior to its manufacture elsewhere.

The nature of the antibody in the delayed type of sensitization is still a matter for argument. We are assuming that practically all workers in this field would agree that the delayed types of allergic sensitization, which comprise the bacterial (tuberculin) and the eczematous (contact) varieties, are brought about by antibodies or an antibody-like material. While any remarks that we may make probably apply to both varieties of the

References 5 and 6.
References 7 and 8.
References 9 to 12.
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Haxthausen, H.:  The Occurrence of Humoral Antibodies in Allergic Eczema Investigated Through Parabiosis Experiments on Guinea Pigs ,  Acta dermat.-venereol. 24:286, 1943.
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Rostenberg, A., Jr.:  Concepts of Allergic Sensitizations: Their Role in Producing Occupational Dermatoses ,  Indust. Med. 23:1, 1954.
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Lenman, J. T.; Bierman, H. R., and Byron, R. L., Sr.:  Transfusion of Leukemic Leukocytes in Man ,  Blood 5:1099, 1950.
Rostenberg, A., Jr., and Kanof, N. M.:  Studies on Eczematous Sensitizations: The Specificity of the Sensitization from the Point of View of Chemical Configuration ,  J. Invest. Dermat. 6:201, 1945.
Eisen, H. N.; Orris, L., and Gelman, S.:  Elicitation of Delayed Allergic Skin Reactions with Haptens: The Dependence of Elicitation on Hapten Combination with Protein ,  J. Exper. Med. 95:473, 1952.
Rostenberg, A., Jr.:  A Study of Sensitization of 2: 4 Dinitrochlorobenzene, to Metadinitrobenzene, and Their Interrelations ,  J. Invest. Dermat. , to be published.
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Hartley, G., Jr.:  The Local Formation of Antivaccinial Antibodies by the Skin ,  J. Infect. Dis. 66:44-52, 1940.