Association Between Superficial Vein Thrombosis and Deep Vein Thrombosis of the Lower Extremities | Cardiology | JAMA Dermatology | JAMA Network
[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
Decousus  HLeizorovicz  A Superficial thrombophlebitis of the legs: still a lot to learn.  J Thromb Haemost20053611491151PubMedGoogle Scholar
Coon  WWWillis  PW  IIIKeller  JB Venous thromboembolism and other venous disease in the Tecumseh community health study.  Circulation1973484839846PubMedGoogle Scholar
Marchiori  AMosena  LPrandoni  P Superficial vein thrombosis: risk factors, diagnosis, and treatment.  Semin Thromb Hemost2006327737743PubMedGoogle Scholar
Decousus  HEpinat  MGuillot  KQuenet  SBoissier  CTardy  B Superficial vein thrombosis: risk factors, diagnosis, and treatment.  Curr Opin Pulm Med200395393397PubMedGoogle Scholar
Quenet  SLaporte  SDecousus  H  et al Factors predictive of venous thrombotic complications in patients with isolated superficial vein thrombosis.  J Vasc Surg2003385944949PubMedGoogle Scholar
Martinelli  ICattaneo  MTaioli  EDe Stefano  VChiusolo  PMannucci  PM Genetic risk factors for superficial vein thrombosis.  Thromb Haemost199982412151217PubMedGoogle Scholar
Verlato  FZucchetta  PPrandoni  P  et al An unexpectedly high rate of pulmonary embolism in patients with superficial thrombophlebitis of the thigh.  J Vasc Surg199930611131115PubMedGoogle Scholar
Superficial Thrombophlebitis Treated by Enoxaparin Study Group A pilot randomized double-blind comparison of low-molecular-weight heparin, nonsteroidal anti-inflammatory agent, and placebo in the treatment of superficial vein thrombosis.  Arch Intern Med20031631416571663PubMedGoogle Scholar
Belcaro  GNicolaides  ANErrichi  BM  et al Superficial thrombophlebitis of the legs: a randomized, controlled, follow-up study.  Angiology1999507523529PubMedGoogle Scholar
Bergstrom  NBraden  BJLaguzza  AHolman  V The Braden scale for predicting pressure sore risk.  Nurs Res1987364205210PubMedGoogle Scholar
Wichers  IMDi Nisio  MBüller  HRMiddeldorp  S Treatment of superficial vein thrombosis to prevent deep vein thrombosis and pulmonary embolism: a systematic review.  Haematologica2005905672677PubMedGoogle Scholar
Bergqvist  DJaroszewski  H Deep vein thrombosis in patients with superficial thrombophlebitis of the leg.  Br Med J (Clin Res Ed)19862926521658659PubMedGoogle Scholar
Lutter  KSKerr  TMRoedersheimer  LRLohr  JMSampson  MGCranley  JJ Superficial thrombophlebitis diagnosed by duplex scanning.  Surgery199111014246PubMedGoogle Scholar
Jorgensen  JOHanel  KCMorgan  AMHunt  JM The incidence of deep venous thrombosis in patients with superficial thrombophlebitis of the lower limb.  J Vasc Surg19931817073PubMedGoogle Scholar
Leon  LGiannoukas  ADDodd  DChan  PLabropoulos  N Clinical significance of superficial vein thrombosis.  Eur J Vasc Endovasc Surg20052911017PubMedGoogle Scholar
Aguilar  Cdel Villar  V D-dimer is not useful for the diagnosis of isolated superficial venous thrombosis.  Am J Med2005118121417PubMedGoogle Scholar
Gillet  JLFfrench  PHanss  MAllaert  FAChleir  F Predictive value of D-dimer assay in superficial thrombophlebitis of the lower limb.  J Mal Vasc20073229095PubMedGoogle Scholar
Wells  PSAnderson  DRRodger  M  et al Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis.  N Engl J Med20033491312271235PubMedGoogle Scholar
Kyrle  PAEichinger  S Deep vein thrombosis.  Lancet2005365946511631174PubMedGoogle Scholar
Righini  MPerrier  ADe Moerloose  PBounameaux  H D-dimer for venous thrombembolism diagnosis: 20 years later.  J Thromb Haemost20086710591071PubMedGoogle Scholar
July 2009

Association Between Superficial Vein Thrombosis and Deep Vein Thrombosis of the Lower Extremities

Author Affiliations

Author Affiliations: Department of Dermatology (Drs Binder, Salmhofer, and Hofmann-Wellenhof), Medical University of Graz (Mss Kroemer and Custovic); and Institute of Medical Engineering, University of Technology (Mr Lackner), Graz, Austria.

Arch Dermatol. 2009;145(7):753-757. doi:10.1001/archdermatol.2009.123

Objective  To evaluate the occurrence of deep vein thrombosis (DVT) in patients with superficial vein thrombosis (SVT).

Design  A prospective study in patients with sonographically proven SVT.

Setting  Outpatient department of the Department of Dermatology, Medical University of Graz.

Patients  Forty-six consecutive patients with superficial vein thrombosis were enrolled.

Intervention  Every patient underwent color-coded duplex sonography of both lower extremities at the beginning of the study.

Main Outcome Measures  Important risk factors (eg, history of thromboembolic events, recent immobilization, active malignant disease, and the use of oral contraceptives) were investigated.

Results  In 24% of our patients, a concomitant, mostly asymptomatic DVT was found. In 73% of these patients, the DVT occurred in the affected leg, in 9% in the contralateral leg, and in 18% in both legs. The calf muscle veins were most commonly involved. In all patients with DVT, the SVT was located on the lower leg and the D-dimer findings were positive.

Conclusions  Superficial vein thrombosis is not a life-threatening disease, but the risk of concomitant DVT cannot be ignored. Color-coded duplex sonography should be performed in patients with SVT to rule out DVT.