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December 2018 - January 1920




January 2019, Vol 155, No. 1, Pages 5-126

In This Issue of JAMA Dermatology


Abstract Full Text
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JAMA Dermatol. 2019;155(1):5. doi:10.1001/jamadermatol.2018.3493

Cutaneous Sensitization to Peanut in Children With Atopic Dermatitis: A Window to Prevention of Peanut Allergy

Abstract Full Text
JAMA Dermatol. 2019;155(1):13-14. doi:10.1001/jamadermatol.2018.3722

This Viewpoint discusses recent findings associating atopic dermatitis in infants with increased sensitization to peanut protein and how those findings are informing new guidelines and efforts to prevent peanut allergy.


Pricing a Year of Progression-Free Survival: When Is the Cost of Cancer Drugs Unreasonable?

Abstract Full Text
JAMA Dermatol. 2019;155(1):15-16. doi:10.1001/jamadermatol.2018.3753

Necrotizing Neutrophilic Dermatitis, an Often-Misdiagnosed Entity With Potentially Severe Consequences

Abstract Full Text
JAMA Dermatol. 2019;155(1):17-18. doi:10.1001/jamadermatol.2018.3788
Original Investigation

Economic Evaluation of Talimogene Laherparepvec Plus Ipilimumab Combination Therapy vs Ipilimumab Monotherapy in Patients With Advanced Unresectable Melanoma

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JAMA Dermatol. 2019;155(1):22-28. doi:10.1001/jamadermatol.2018.3958

This economic evaluation assesses the cost-effectiveness of talimogene laherparepvec plus ipilimumab combination therapy vs ipilimumab monotherapy in patients with advanced unresectable melanoma from the perspective of public and private US payers.

Benefits and Harms of Omalizumab Treatment in Adolescent and Adult Patients With Chronic Idiopathic (Spontaneous) Urticaria: A Meta-analysis of “Real-world” Evidence

Abstract Full Text
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JAMA Dermatol. 2019;155(1):29-38. doi:10.1001/jamadermatol.2018.3447

This meta-analysis of 67 observational studies analyzes the effectiveness and adverse event rate of omalizumab therapy in patients with chronic idiopathic urticaria and compares these findings with those of randomized clinical trials conducted among similar patients.

Association of Phenotypic Characteristics and UV Radiation Exposure With Risk of Melanoma on Different Body Sites

Abstract Full Text
JAMA Dermatol. 2019;155(1):39-49. doi:10.1001/jamadermatol.2018.3964

This population-based cohort study uses data from the Norwegian Women and Cancer study to investigate the association between phenotypic characteristics, pattern of UV radiation exposure, and risk of melanoma on different body sites.

Genetic, Clinical, and Environmental Factors Associated With Persistent Atopic Dermatitis in Childhood

Abstract Full Text
JAMA Dermatol. 2019;155(1):50-57. doi:10.1001/jamadermatol.2018.4061

This clinical birth cohort study evaluates the association of genetic, environmental, clinical, and social factors with the persistence of atopic dermatitis at age 13 years among children born to parents with asthma.

Expert-Level Diagnosis of Nonpigmented Skin Cancer by Combined Convolutional Neural Networks

Abstract Full Text
JAMA Dermatol. 2019;155(1):58-65. doi:10.1001/jamadermatol.2018.4378

This study compares the accuracy of a convolutional neural network–based classifier with that of physicians with different levels of experience at classifying dermoscopic and close-up images of nonpigmented lesions.

Aggressive Squamous Cell Carcinoma in Organ Transplant Recipients

Abstract Full Text
JAMA Dermatol. 2019;155(1):66-71. doi:10.1001/jamadermatol.2018.4406

This case series describes the clinicopathologic features of and identifies factors associated with aggressive squamous cell carcinoma in solid organ transplant recipients.

Use of Big Data to Estimate Prevalence of Defective DNA Repair Variants in the US Population

Abstract Full Text
JAMA Dermatol. 2019;155(1):72-78. doi:10.1001/jamadermatol.2018.4473

This molecular epidemiologic study examinsd 3 large exome sequence databases totaling more than 200 000 alleles to correlate disease-associated allele frequencies with the expected and reported prevalence of clinical disease.

Brief Report

Clinical Features of Neutrophilic Dermatosis Variants Resembling Necrotizing Fasciitis

Abstract Full Text
JAMA Dermatol. 2019;155(1):79-84. doi:10.1001/jamadermatol.2018.3890

This case series examines 6 previously unreported patients and published reports of 48 patients with necrotizing neutrophilic dermatosis to identify the traits and infection-mimicking features of a new subset of necrotizing neutrophilic dermatosis.

Association of Quality of Life With Surgical Excision of Early-Stage Melanoma of the Head and Neck

Abstract Full Text
JAMA Dermatol. 2019;155(1):85-89. doi:10.1001/jamadermatol.2018.3409

This study examines the preoperative and postoperative changes in quality of life as perceived and reported by patients who received surgical treatment for Tis or T1a melanoma of the head and neck.

Use of Dapsone in the Treatment of Chronic Idiopathic and Autoimmune Urticaria

Abstract Full Text
JAMA Dermatol. 2019;155(1):90-95. doi:10.1001/jamadermatol.2018.3715

This medical record review evaluates the efficacy and safety of dapsone as second-line therapy in patients with chronic spontaneous urticaria.


Association Between Psoriasis and Sexual and Erectile Dysfunction in Epidemiologic Studies: A Systematic Review

Abstract Full Text
JAMA Dermatol. 2019;155(1):98-106. doi:10.1001/jamadermatol.2018.3442

This systematic review evaluates the main characteristics of the studies of psoriasis and sexual dysfunction (SD) or erectile dysfunction (ED), including level of evidence, tools used to assess SD or ED, and prevalence and incidence of SD or ED.

Images in Dermatology

Coral Dermatitis

Abstract Full Text
JAMA Dermatol. 2019;155(1):107. doi:10.1001/jamadermatol.2018.3592

This case report describes a cerebriform plaque with sharply demarcated, pink, erythematous borders on the leg of a woman after she came in contact with coral.

Herpes-Associated Erythema Multiforme

Abstract Full Text
JAMA Dermatol. 2019;155(1):108. doi:10.1001/jamadermatol.2018.3973

This case report describes the occurrence of herpes-associated erythema multiforme.

JAMA Dermatology Clinicopathological Challenge

Palatal Swelling in a Patient With Refractory Leukemia

Abstract Full Text
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JAMA Dermatol. 2019;155(1):109-110. doi:10.1001/jamadermatol.2018.2299

A man in his 20s with acute myeloid leukemia presented with rapidly growing, severely painful oral lesions on the left hard palate. What is your diagnosis?

A Child With Multiple Hypopigmented Macules on the Abdomen

Abstract Full Text
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JAMA Dermatol. 2019;155(1):111-112. doi:10.1001/jamadermatol.2018.2362

A child presented with multiple, asymptomatic, scattered white macules on the lower abdomen and pubic area, which were present at birth and had gradually increased in size and number; there was no history of any systemic disorder and no family history of similar lesions. What is your diagnosis?

Necrotic Plaque on the Distal Nose With Diffuse Crateriform Nodules

Abstract Full Text
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JAMA Dermatol. 2019;155(1):113-114. doi:10.1001/jamadermatol.2018.2552

A man in his 30s presented with a progressively necrotic plaque on the nose, scattered nodules on the extremities, and erythematous papules on the arms and legs. What is your diagnosis?

Research Letter

α-Gal Syndrome vs Chronic Urticaria

Abstract Full Text
JAMA Dermatol. 2019;155(1):115-116. doi:10.1001/jamadermatol.2018.3970

This cohort study assesses the use of a blood test to distinguish galactose-α-1,3-galactose (α-gal) allergy from chronic urticaria.

Comparison of Injuries From Sharps Among Resident Physicians Within Dermatology and Other Medical and Surgical Specialties

Abstract Full Text
JAMA Dermatol. 2019;155(1):116-118. doi:10.1001/jamadermatol.2018.4468

This study assesses whether the nature of injuries from sharps among dermatology residents is demonstrably different compared with injuries from sharps among residents in other medical and surgical specialties.


Dupilumab Treatment for Generalized Prurigo Nodularis

Abstract Full Text
JAMA Dermatol. 2019;155(1):118-120. doi:10.1001/jamadermatol.2018.3912

This case series report of 3 patients assesses the effectiveness of dupilumab in the treatment of generalized prurigo nodularis.

Patch Testing and Allergen-Specific Inhibition in a Patient Taking Dupilumab

Abstract Full Text
JAMA Dermatol. 2019;155(1):120-121. doi:10.1001/jamadermatol.2018.4098

This case report describes changes in repeated patch test results in a patient receiving dupilumab therapy.

Reduced Itch Associated With Dupilumab Treatment In 4 Patients With Prurigo Nodularis

Abstract Full Text
JAMA Dermatol. 2019;155(1):121-122. doi:10.1001/jamadermatol.2018.3906

This case report describes itch reduction in 4 patients with prurigo nodularis following treatment with dupilumab.

Metastatic Calcinosis Cutis Associated With a Selective FGFR Inhibitor

Abstract Full Text
JAMA Dermatol. 2019;155(1):122-123. doi:10.1001/jamadermatol.2018.4070

This case report describes metastatic calcinosis cutis associated with selective FGFR inhibitor therapy.

Comment & Response

Use of Combination Systemic-Intratumoral HPV Vaccine to Treat Cutaneous Basaloid Squamous Cell Carcinomas

Abstract Full Text
JAMA Dermatol. 2019;155(1):123-124. doi:10.1001/jamadermatol.2018.3789

Use of Combination Systemic-Intratumoral HPV Vaccine to Treat Cutaneous Basaloid Squamous Cell Carcinomas—Reply

Abstract Full Text
JAMA Dermatol. 2019;155(1):124-125. doi:10.1001/jamadermatol.2018.3651

Creating a Partnership Between Dermatologists and Geriatricians

Abstract Full Text
JAMA Dermatol. 2019;155(1):125. doi:10.1001/jamadermatol.2018.3727

Creating a Partnership Between Dermatologists and Geriatricians—Reply

Abstract Full Text
JAMA Dermatol. 2019;155(1):125-126. doi:10.1001/jamadermatol.2018.3660
JAMA Dermatology Masthead

JAMA Dermatology

Abstract Full Text
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JAMA Dermatol. 2019;155(1):8. doi:10.1001/jamadermatol.2018.3494