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September 2019 - January 1920

Decade

Year

Issue

December 20, 2010, Vol 146, No. 12, Pages 1339-1444

Editorial

Extensive Slow-Flow Vascular Malformations and Pulmonary Hypertension

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Arch Dermatol. 2010;146(12):1416-1418. doi:10.1001/archdermatol.2010.377
Study

Pulmonary Arterial Hypertension in Patients With Slow-Flow Vascular Malformations

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Arch Dermatol. 2010;146(12):1347-1352. doi:10.1001/archdermatol.2010.379

Prevalence and Characteristics of Indoor Tanning Use Among Men and Women in the United States

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Arch Dermatol. 2010;146(12):1356-1361. doi:10.1001/archdermatol.2010.355

Alcohol Intake and Risk of Incident Psoriasis in US Women: A Prospective Study

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Arch Dermatol. 2010;146(12):1364-1369. doi:10.1001/archdermatol.2010.204

Drug Reaction With Eosinophilia and Systemic Symptoms: A Retrospective Study of 60 Cases

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Arch Dermatol. 2010;146(12):1373-1379. doi:10.1001/archdermatol.2010.198
ObjectiveTo investigate the clinical and pathologic features of patients with drug reaction with eosinophilia and systemic symptoms (DRESS) in Taiwan.DesignCase series and retrospective analysis.SettingA medical referral center in Northern Taiwan.PatientsSixty cases of DRESS occurring from June 1998 to May 2008.Main Outcome MeasuresClinical characteristics for specific drugs and important prognostic factors in DRESS.ResultsPatients ranged in age from 6 to 90 years (mean age, 51 years). The female to male ratio was 1.3 to 1. The most common culprit drugs were allopurinol, phenytoin, and dapsone. Exanthematous eruption was the most common skin manifestation, but purpurae and blisters were also observed. Hepatic (80%), renal (40%), and pulmonary (33%) involvement were also common. The overall mortality rate was 10%. Allopurinol-induced DRESS was characterized by preceding chronic renal insufficiency and frequent renal involvement. Pancytopenia indicated a poor prognosis.ConclusionsDrug reaction with eosinophilia and systemic symptoms has a variable clinical presentation, and its definition requires clarification. It may be a heterogeneous syndrome with some particular patterns related to different drugs. Early diagnosis and prompt discontinuation of offending drug regimens are essential.

Increased Programmed Death-1 Expression on CD4+ T Cells in Cutaneous T-Cell Lymphoma: Implications for Immune Suppression

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Arch Dermatol. 2010;146(12):1382-1388. doi:10.1001/archdermatol.2010.200
ObjectivesTo investigate the expression profile of programmed death-1 (PD-1) on T cells derived from patients with cutaneous T-cell lymphoma (CTCL), analyze a potential mechanism responsible for upregulation of PD-1, and assess the correlation between blockade of its signaling pathway and improvement in immunological function.DesignTranslation research study.SettingUniversity medical center.ParticipantsPatients with Sézary syndrome, patients with mycosis fungoides, and healthy volunteers.Main Outcome MeasuresProgrammed death-1 expression on T cells by flow cytometry and interferon γ (IFN-γ) production by enzyme-linked immunosorbent assay.ResultsWe report significantly increased PD-1 expression on CD4+ T cells from patients with Sézary syndrome compared with CD4+ T cells from patients with mycosis fungoides and healthy volunteers. Both CD26 and CD26+ populations of CD4+ T cells demonstrated increased expression of PD-1, which was upregulated by the engagement of the T-cell receptor with anti-CD3/CD28 antibodies. In addition, blockade of the signaling pathway with blocking antibodies to PD-1 or its ligand PD-L1 led to an increase in the capacity to produce IFN-γ among some patients. Finally, longitudinal studies of 1 patient revealed a progressive decrease in PD-1 expression on CD4+ T cells with improvement of clinical disease.ConclusionOur data imply that increased PD-1 expression in Sézary syndrome may play a role in attenuating the immune response and provide further insight into the immunosuppressive nature of CD4+ T cells in Sézary syndrome and suggest another potential means of targeted therapy for these patients.
skINsight

The Zig-Zag Pattern of Lentigo Maligna

Abstract Full Text
Arch Dermatol. 2010;146(12):1444. doi:10.1001/archdermatol.2010.307
The Cutting Edge: Challenges in Medical and Surgical Therapies

Severe Refractory Hidradenitis Suppurativa in an HIV-Positive Patient Successfully Treated With Infliximab

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Arch Dermatol. 2010;146(12):1343-1345. doi:10.1001/archdermatol.2010.372
Research Letter

The Effect of Initial Indoor Tanning With Mother on Current Tanning Patterns

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Arch Dermatol. 2010;146(12):1427-1439. doi:10.1001/archdermatol.2010.349

A Randomized Controlled Pilot Study of the Effects of an Extra Office Visit on Adherence and Outcomes in Atopic Dermatitis

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Arch Dermatol. 2010;146(12):1428-1431. doi:10.1001/archdermatol.2010.368

Practice Gaps—Failure to Maximize Patient Adherence Strategies in Clinical Practice

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Arch Dermatol. 2010;146(12):1430-1431. doi:10.1001/archdermatol.2010.348

Phase 1 Clinical Trial of Intralesional Injection of Candida Antigen for the Treatment of Warts

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Arch Dermatol. 2010;146(12):1431-1433. doi:10.1001/archdermatol.2010.350
Observation

Association of Hearing Loss With PHACE Syndrome

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Arch Dermatol. 2010;146(12):1391-1396. doi:10.1001/archdermatol.2010.201
BackgroundPHACE syndrome describes a spectrum of anomalies associated with large facial infantile hemangiomas and characterized by posterior fossa malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities. With improved recognition and imaging practices of infants with PHACE syndrome, additional associations have been identified. To our knowledge, the potential association of ipsilateral hearing loss and PHACE syndrome has not been previously emphasized.ObservationsWe describe 6 patients, 4 with definite and 2 with probable PHACE syndrome, according to the new diagnostic criteria, and associated auditory deficiencies. One patient had isolated conductive hearing loss; 2 patients had isolated sensorineural hearing loss; 1 patient had mixed hearing loss (both conductive and sensorineural components); and 1 patient had hearing loss that was inconclusive at the time. Also, 1 patient had conductive loss and auditory neuropathy and auditory dyssynchrony. Four of the 6 patients had magnetic resonance imaging features of lesions consistent with intracranial hemangiomas involving auditory structures. All 6 patients had facial hemangiomas in a nearly identical distribution ipsilateral to the ear with the hearing loss, with involvement of the proposed facial segments S1 and S3, the affected ear, the periauricular region, and the midoccipital area of the scalp.ConclusionsThere is an underrecognized risk of hearing loss in patients with PHACE syndrome, although the exact nature of such deficiencies can vary. Patients with PHACE syndrome who have cutaneous hemangiomas involving the ear should be evaluated for intracranial hemangiomas and monitored for hearing loss. Early detection and therapy of intracranial hemangiomas may slow or stop tumor growth, resultant hearing loss, and structural damage.

Atypical Fibroxanthoma With Regional Lymph Node Metastasis: Report of a Case and Review of the Literature

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Arch Dermatol. 2010;146(12):1399-1404. doi:10.1001/archdermatol.2010.206
BackgroundAtypical fibroxanthoma (AFX) is a low-grade sarcoma usually occurring on sun-damaged skin of the head and neck in elderly patients. Metastatic disease has been reported very rarely. The potential aggressiveness of AFX is controversial.ObservationsWe describe herein a patient who developed metastatic disease in cervical lymph nodes. Our patient was an 87-year-old man with a 7-week history of a rapidly growing AFX presenting as a 1.5-cm sessile nodule on his right mandible. Two months following excision, the patient developed cervical lymphadenopathy. Histopathologic analysis of the cervical lymph nodes revealed spindle-cell tumors with histologic characteristics identical to those of the primary AFX, and the tumors were immunonegative for cytokeratin MNF-116 and S-100. In addition, we review and analyze cases from the literature and articles related to immunohistochemical stains used to diagnose AFX.ConclusionsAtypical fibroxanthoma is a diagnosis of exclusion, and only a small number of metastatic AFX cases have been reported. A review of the literature pertaining to immunohistochemical stains suggests the potential benefit of use of CD10, procollagen I, CD99, CD117, p63, and LN-2 in differentiating AFX from other spindle-cell tumors. The metastatic potential of AFX may not be fully appreciated, and clinicians should be reminded of its potential aggressive behavior.

Becker Nevus With an Underlying Desmoid Tumor: A Case Report and Review Including Mayo Clinic's Experience

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Arch Dermatol. 2010;146(12):1408-1412. doi:10.1001/archdermatol.2010.369
The Best of the Best

Top-Accessed Article: Glycolic Acid Peels in the Treatment of Melasma

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Arch Dermatol. 2010;146(12):1439. doi:10.1001/archdermatol.2010.352
Announcement

Thank You to Our Reviewers

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Arch Dermatol. 2010;146(12):1352. doi:10.1001/archdermatol.2009.1352
Annual Reviewers List

Annual Reviewers List

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Arch Dermatol. 2010;146(12):1340. doi:10.1001/archdermatol.2010.380
Archives a Century Ago

Granuloma Pyogenicum.

Abstract Full Text
Arch Dermatol. 2010;146(12):1342. doi:10.1001/archdermatol.2010.345
Practice Gaps
Archives Web Quiz Winner

September 2010 Archives Web Quiz Winner

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Arch Dermatol. 2010;146(12):1362. doi:10.1001/archdermatol.2010.351

Failure to Counsel Patients With Psoriasis to Decrease Alcohol Consumption (and Smoking): Comment on “Alcohol Intake and Risk of Incident Psoriasis in US Women”

Abstract Full Text
Arch Dermatol. 2010;146(12):1370. doi:10.1001/archdermatol.2010.373

Failure to Recognize and Manage Patients With DRESS: Comment on “Drug Reaction With Eosinophilia and Systemic Symptoms” Failure to Recognize Patients With DRESS

Abstract Full Text
Arch Dermatol. 2010;146(12):1379. doi:10.1001/archdermatol.2010.361
Off-Center Fold

Generalized Flesh-Colored Papules in a 5-Year-Old Boy—Quiz Case

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Arch Dermatol. 2010;146(12):1419-1424. doi:10.1001/archdermatol.2010.356-a

Generalized Flesh-Colored Papules in A 5-Year-Old Boy—Diagnosis

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Arch Dermatol. 2010;146(12):1419-1424. doi:10.1001/archdermatol.2010.356-b

An Unusual Case of Palmoplantar Keratoderma—Quiz Case

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Arch Dermatol. 2010;146(12):1419-1424. doi:10.1001/archdermatol.2010.357-a

An Unusual Case of Palmoplantar Keratoderma—Diagnosis

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Arch Dermatol. 2010;146(12):1419-1424. doi:10.1001/archdermatol.2010.357-b

Pruritic Maculopapular Dermatitis in a Household—Quiz Case

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Arch Dermatol. 2010;146(12):1419-1424. doi:10.1001/archdermatol.2010.358-a

Pruritic Maculopapular Dermatitis in a Household—Diagnosis

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Arch Dermatol. 2010;146(12):1419-1424. doi:10.1001/archdermatol.2010.358-b

Erythroderma and Spontaneous Blistering in a 49-Year-Old Man—Quiz Case

Abstract Full Text
Arch Dermatol. 2010;146(12):1419-1424. doi:10.1001/archdermatol.2010.359-a

Erythroderma and Spontaneous Blistering in a 49-Year-Old Man—Diagnosis

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Arch Dermatol. 2010;146(12):1419-1424. doi:10.1001/archdermatol.2010.359-b
Correspondence

Multiple Myeloma–Associated Amyloidosis Presenting With Acrolocalized Acquired Cutis Laxa

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Arch Dermatol. 2010;146(12):1435-1437. doi:10.1001/archdermatol.2010.365

Minoxidil-Induced Trichostasis Spinulosa of Terminal Hair

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Arch Dermatol. 2010;146(12):1437-1438. doi:10.1001/archdermatol.2010.363

HLA-B*1502 Allele Associated With Carbamazepine-Induced Epidermal Necrolysis

Abstract Full Text
Arch Dermatol. 2010;146(12):1437-1438. doi:10.1001/archdermatol.2010.364

Sporotrichoid Staphylococcus aureus Infection in an Immunosuppressed Patient

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Arch Dermatol. 2010;146(12):1438-1439. doi:10.1001/archdermatol.2010.366

Regional Squamous Cell Carcinomas Following Systemic Sorafenib Therapy and Isolated Limb Infusion for Regionally Advanced Metastatic Melanoma of the Limb

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Arch Dermatol. 2010;146(12):1438-1439. doi:10.1001/archdermatol.2010.367

Our Thanks to ARCHIVES Peer Reviewers

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Arch Dermatol. 2010;146(12):E1-E3. doi:10.1001/archdermatol.2010.360
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