Roujeau et al evaluate the incidence, type, and severity of telaprevir-associated skin reactions. Data from 3 international phase 3 studies of telaprevir in combination with interferon and ribavirin.
Objective To determine whether the extent, distribution, and duration of vitiligo are associated with impairment of specific aspects of quality of life.
Design A prospective questionnaire-based study of 1541 adults with vitiligo.
Setting Online questionnaire.
Main Outcome Measures Affected body surface area (BSA), distribution and duration of vitiligo, associated symptoms, and quality of life using the Dermatology Life Quality Index (DLQI).
Results Vitiligo had a negative effect on numerous aspects and the total score of the DLQI (mean [SD], 5.9 [5.5]). The DLQI scores in vitiligo were associated with an affected BSA of more than 25% (ordinal logistic regression; adjusted odds ratio, 2.17 [95% CI, 1.71-2.75; P < .001]) and number of body parts affected with vitiligo (P ≤ .009) but not laterality (P = .06) or duration of disease (P ≥ .54). Itching and/or burning skin occurred in a sizable percentage of vitiligo patients (35.1%) and were predicted by an affected BSA of more than 25% (adjusted odds ratio, 1.59 [95% CI, 1.26-2.01; P < .001]). Sexual dysfunction occurred in 18% of patients and was predicted by an affected BSA of more than 25% (adjusted odds ratio, 1.94 [95% CI, 1.44-2.61; P < .001]) and vitiligo lesions in the genital area (1.82 [1.30-2.53; P < .001]).
Conclusions Vitiligo extent is associated with increased quality-of-life impairment, including itching and sexual dysfunction. Moreover, different distributions of vitiligo lesions are associated with impairment of different aspects of quality of life.
Trial Registration clinicaltrials.gov Identifier: NCT01401374
Paller et al conducted an international study to evaluate the association between adiposity and the severity of psoriasis in children.
Belkin and colleagues characterize the presence of CD200 and CD200 receptor in cutaneous squamous cell carcinoma (SCC) microenvironment and propose a role for the CD200 axis in immune evasion by SCC.
Etminan et al examine the association between isotretinoin and the risk for inflammatory bowel disease (IBD) among women in a case-control study of a health claims database and a meta-analysis of previous studies. See also the editorial by Popescu and Bigby.
Fajgenbaum et al report a case of eruptive cherry hemangiomatosis (ECH) the heralding sign of multicentric Castleman disease that occurred in a 25-year-old man with a 10-year history of benign vascular growths. The authors propose a possible mechanism and suggest that patients presenting with eruptive cherry hemangiomatosis (ECH) in the setting of systemic symptoms, should be fully evaluated for the potential development of multicentric Castleman disease and other lymphoproliferative diseases.
Weitz et al report 7 cases of contact dermatitis at the site of central access catheters treated with chlorhexidine gluconate–impregnated dressings.
Thornsberry and English retrospectively reviewed the medical records of 15 women with scalp dysesthesia and cervical spine images. A gabapentin regimen (topical or oral) had been recommended to 14 patients, 7 of whom had follow-up data.
Geusau and colleagues diagnosed a patient as having features of a PAPA-like syndrome in which cutaneous manifestation, such as pyoderma gangrenosum and acne fulminans, predominated. Sequencing of the PSTPIP1 gene was performed in the patient and his extended family. The patient was treated with canakinumab.
Create a personal account or sign in to: