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April 2015, Vol 151, No. 4, Pages 361-459

In This Issue of JAMA Dermatology

Highlights

Abstract Full Text
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JAMA Dermatol. 2015;151(4):361. doi:10.1001/jamadermatol.2014.2911
Viewpoint

Using “Big Data” to Optimize Public Health Outreach: Answering the Call to Action

Abstract Full Text
JAMA Dermatol. 2015;151(4):367-368. doi:10.1001/jamadermatol.2014.3176

This Viewpoint examines Google Trends data to show how search engine query data can reveal temporal variations in public interest that can be used to optimize public health initiatives in dermatology.

Editorial

How Likely Is Another Nonmelanoma Skin Cancer?Better Informing Patients and Clinicians

Abstract Full Text
JAMA Dermatol. 2015;151(4):369-370. doi:10.1001/jamadermatol.2014.3827

What Dermatology Still Needs to Create Meaningful Patient Outcome Measurements

Abstract Full Text
JAMA Dermatol. 2015;151(4):371-372. doi:10.1001/jamadermatol.2014.3514
Original Investigation

Using the Physician Global Assessment in a Clinical Setting to Measure and Track Patient Outcomes

Abstract Full Text
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JAMA Dermatol. 2015;151(4):375-381. doi:10.1001/jamadermatol.2014.3513

This Original Investigation proposes that the Physician Global Assessment is a potentially useful tool to track acne and psoriasis outcomes over time.

Timing of Subsequent New Tumors in Patients Who Present With Basal Cell Carcinoma or Cutaneous Squamous Cell Carcinoma

Abstract Full Text
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JAMA Dermatol. 2015;151(4):382-388. doi:10.1001/jamadermatol.2014.3307

This prospective observational cohort study finds that among patients with first keratinocyte carcinoma, a subset may not develop a subsequent tumor. Results were consistent for basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (SCC).

Promoting Safe Use of Isotretinoin by Increasing Contraceptive Knowledge

Abstract Full Text
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JAMA Dermatol. 2015;151(4):389-393. doi:10.1001/jamadermatol.2014.4171

This survey study found that a contraceptive information sheet can significantly improve patients’ contraceptive knowledge and may be a useful addition to efforts to prevent isotretinoin-induced birth defects.

Bilateral Lower Extremity Inflammatory Lymphedema in Air Force Basic Trainees: Clinical and Epidemiologic Study of a New Disease Entity

Abstract Full Text
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JAMA Dermatol. 2015;151(4):395-400. doi:10.1001/jamadermatol.2014.3794

This observational study rules out training-related risk factors as the sources of bilateral lower extremity inflammatory lymphedema in Air Force basic trainees.

Association Between Eczema and Stature in 9 US Population-Based Studies

Abstract Full Text
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JAMA Dermatol. 2015;151(4):401-409. doi:10.1001/jamadermatol.2014.3432

Data from 9 US population-based studies find that a small subset of children and adolescents with severe eczema accompanied by prominent insufficient sleep may have potentially reversible vertical growth impairment.

BRAFV600E Protein Expression in Primary Cutaneous Malignant Melanomas and Paired Metastases

Abstract Full Text
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JAMA Dermatol. 2015;151(4):410-416. doi:10.1001/jamadermatol.2014.3689

This retrospective cohort study found VE1 immunohistochemical analysis to be a useful and rapid assay for BRAFV600E mutations.

Case Report/Case Series

BRAF Wild-Type Melanoma in Situ Arising In a BRAF V600E Mutant Dysplastic Nevus

Abstract Full Text
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JAMA Dermatol. 2015;151(4):417-421. doi:10.1001/jamadermatol.2014.3775

Dermoscopy-targeted sampling and genotyping of a melanoma in situ arising in a dysplastic nevus revealed a phenotype-genotype paradox that confounds the exclusive significance of BRAF and NRAS mutations in melanoma pathogenesis.

Life-Threatening Hemorrhaging in Neonatal Ulcerated Congenital Hemangioma: Two Case Reports

Abstract Full Text
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JAMA Dermatol. 2015;151(4):422-425. doi:10.1001/jamadermatol.2014.3666

This case series describes 2 cases of ulcerated neonatal congenital hemangioma successfully treated with embolization.

Familial Chilblain Lupus Due to a Novel Mutation in the Exonuclease III Domain of 3′ Repair Exonuclease 1 (TREX1)

Abstract Full Text
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JAMA Dermatol. 2015;151(4):426-431. doi:10.1001/jamadermatol.2014.3438

This case implicates type I interferon–dependent innate immune activation in the pathogenesis of TREX1-associated familial chilblain lupus.

Invited Commentary

Practice Gaps

Promoting Safe Use of Isotretinoin by Increasing Contraceptive Knowledge

Abstract Full Text
JAMA Dermatol. 2015;151(4):393-394. doi:10.1001/jamadermatol.2014.4158
Review

Combining Biologic Therapies With Other Systemic Treatments in Psoriasis: Evidence-Based, Best-Practice Recommendations From the Medical Board of the National Psoriasis Foundation

Abstract Full Text
JAMA Dermatol. 2015;151(4):432-438. doi:10.1001/jamadermatol.2014.3456

This Medline database study demonstrates that, among appropriately selected patients with psoriasis, carefully chosen combinations may result in greater efficacy while minimizing toxicity.

JAMA Dermatology Clinicopathological Challenge

Polymorphic Blistering Eruption and Stomatitis in a Patient With Non-Hodgkin Lymphoma

Abstract Full Text
JAMA Dermatol. 2015;151(4):439-440. doi:10.1001/jamadermatol.2014.4361

New Tender Nodules After Arthroscopy

Abstract Full Text
JAMA Dermatol. 2015;151(4):441-442. doi:10.1001/jamadermatol.2014.4872

In this case report, a woman with a history of systemic lupus erythematosus presented with tender erythematous nodules after undergoing right knee arthroscopy. Physical examination revealed poorly demarcated erythematous plaques and nodules, tender to palpation, adjacent to arthroscopy sites. Lesions around the suture sites appeared more violaceous. What is the diagnosis?

Diffuse Papular Eruption

Abstract Full Text
JAMA Dermatol. 2015;151(4):443-444. doi:10.1001/jamadermatol.2014.3653

A papular eruption exhibiting skin-colored to pink papules coalescing into plaques on the face, trunk, and extremities worsened 1 week later with fever, weakness, and malaise and findings of splenomegaly and axillary lymphadenopathy. What is your diagnosis.

Research Letter

Biopsies of Nevi in Children and Adolescents in the United States, 2009 Through 2013

Abstract Full Text
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JAMA Dermatol. 2015;151(4):447-448. doi:10.1001/jamadermatol.2014.4576

Trends in Indoor Tanning Among US High School Students, 2009-2013

Abstract Full Text
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JAMA Dermatol. 2015;151(4):448-450. doi:10.1001/jamadermatol.2014.4677

The Risk of Melanoma in Pilots and Cabin Crew: UV Measurements in Flying Airplanes

Abstract Full Text
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JAMA Dermatol. 2015;151(4):450-452. doi:10.1001/jamadermatol.2014.4643
Observation

Homozygous Missense Mutation in IL36RN in Generalized Pustular Dermatosis With Intraoral Involvement Compatible With Both AGEP and Generalized Pustular Psoriasis

Abstract Full Text
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JAMA Dermatol. 2015;151(4):452-453. doi:10.1001/jamadermatol.2014.3848

Fanconi Syndrome Induced by Vemurafenib: A New Renal Adverse Event

Abstract Full Text
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JAMA Dermatol. 2015;151(4):453-454. doi:10.1001/jamadermatol.2014.4529

Moon Jellyfish Stings

Abstract Full Text
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JAMA Dermatol. 2015;151(4):454-456. doi:10.1001/jamadermatol.2014.4644

High-Dynamic-Range Dermoscopy Imaging and Diagnosis of Hypopigmented Skin Cancers

Abstract Full Text
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JAMA Dermatol. 2015;151(4):456-457. doi:10.1001/jamadermatol.2014.4714
Comment & Response

The Cause of Follicular Spicules in Multiple Myeloma

Abstract Full Text
JAMA Dermatol. 2015;151(4):457-458. doi:10.1001/jamadermatol.2014.4379

Trichodysplasia Spinulosa in Gorlin Syndrome Treated With Vismodegib

Abstract Full Text
JAMA Dermatol. 2015;151(4):458-459. doi:10.1001/jamadermatol.2014.4382

The Cause of Follicular Spicules in Multiple Myeloma—Reply

Abstract Full Text
JAMA Dermatol. 2015;151(4):458. doi:10.1001/jamadermatol.2014.4385

Trichodysplasia Spinulosa in Gorlin Syndrome Treated With Vismodegib—Reply

Abstract Full Text
JAMA Dermatol. 2015;151(4):459. doi:10.1001/jamadermatol.2014.4388
Notable Notes

Everyone’s Got It … It Must Be Familial

Abstract Full Text
JAMA Dermatol. 2015;151(4):388. doi:10.1001/jamadermatol.2014.360

A Quick Review of the Cutaneous Findings of the Deadly Scourge Ebola Virus

Abstract Full Text
JAMA Dermatol. 2015;151(4):400. doi:10.1001/jamadermatol.2014.4505

Frostbite and Chilblains in Upton Sinclair’s The Jungle

Abstract Full Text
JAMA Dermatol. 2015;151(4):421. doi:10.1001/jamadermatol.2014.2343

Scurvy: Curse and Cure in New France

Abstract Full Text
JAMA Dermatol. 2015;151(4):431. doi:10.1001/jamadermatol.2014.4582
JAMA Dermatology Masthead

JAMA Dermatology

Abstract Full Text
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JAMA Dermatol. 2015;151(4):362. doi:10.1001/jamadermatol.2014.2912
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