June 2016, Vol 152, No. 6, Pages 603-736

In This Issue of JAMA Dermatology

Highlights

Abstract Full Text

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JAMA Dermatol. 2016;152(6):603. doi:10.1001/jamadermatol.2015.3261

Viewpoint

Zika Virus in the Americas: An Obscure Arbovirus Comes Calling

Lola V. Stamm, PhD

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JAMA Dermatol. 2016;152(6):621-622. doi:10.1001/jamadermatol.2016.1499

This Viewpoint discusses the spread of the Zika virus in the Americas, the risk of a US outbreak, and what can be done in terms of surveillance and prevention.

Editor's Note
Zika Virus
June K. Robinson, MD

Large Acquired Nevus or Dysplastic Nevus: What’s in the Name of a Nevus?

Rainer Hofmann-Wellenhof, MD; Ashfaq A. Marghoob, MD; Iris Zalaudek, MD

Abstract Full Text

JAMA Dermatol. 2016;152(6):623-624. doi:10.1001/jamadermatol.2015.6186

This Viewpoint discusses use of the term large acquired nevus vs dysplastic nevus.

A Policy-Driven Perspective on Rising Drug Costs in Dermatology

Harrison P. Nguyen, BS; Howard P. Forman, MD, MBA

Abstract Full Text

JAMA Dermatol. 2016;152(6):625-626. doi:10.1001/jamadermatol.2016.0349

This Viewpoint examines the causes of rising drug costs in dermatology.

Editorial

JAMA Dermatology—The Year in Review, 2015

June K. Robinson, MD; Jeffrey P. Callen, MD

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JAMA Dermatol. 2016;152(6):627-628. doi:10.1001/jamadermatol.2016.1139

Cost of Inpatient Care of Patients With Pemphigus in the United States: Translating Dollars and Cents Into Improved Patient Care

Adela R. Cardones, MD; Russell P. Hall III, MD

Abstract Full Text

JAMA Dermatol. 2016;152(6):629-630. doi:10.1001/jamadermatol.2015.5241

Photodynamic Therapy in Daylight for Actinic Keratoses

Hans Christian Wulf, MD, DMSc, PharmD

Abstract Full Text

JAMA Dermatol. 2016;152(6):631-632. doi:10.1001/jamadermatol.2015.5979

Original Investigation

Artificial White Light vs Daylight Photodynamic Therapy for Actinic Keratoses: A Randomized Clinical Trial

Susan M. O’Gorman, MBBCh; Julianne Clowry, MBBCh; Michael Manley, MSc; et al.

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JAMA Dermatol. 2016;152(6):638-644. doi:10.1001/jamadermatol.2015.5436

This clinical trial compares the effectiveness of daylight vs artificial white light with topical methyl 5-aminolevulinic acid photodynamic therapy for actinic keratoses in a cohort of 22 men.

Editorial
Photodynamic Therapy in Daylight for Actinic Keratoses
Hans Christian Wulf, MD, DMSc, PharmD

Costs of Care for Hospitalization for Pemphigus in the United States

Derek Hsu, BA; Joaquin Brieva, MD; Jonathan I. Silverberg, MD, PhD, MPH

Abstract Full Text

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JAMA Dermatol. 2016;152(6):645-654. doi:10.1001/jamadermatol.2015.5240

This study examines the incidence of and risk factors for hospitalization for patients with pemphigus and cost of care.

Editorial
Cost of Inpatient Care of Patients With Pemphigus in the United States: Translating Dollars and Cents Into Improved Patient Care
Adela R. Cardones, MD; Russell P. Hall III, MD

Modeling the Effect of Shared Care to Optimize Acne Referrals From Primary Care Clinicians to Dermatologists

Kristina J. Liu, MD; Rebecca I. Hartman, MD, MPH; Cara Joyce, PhD; et al.

Abstract Full Text

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JAMA Dermatol. 2016;152(6):655-660. doi:10.1001/jamadermatol.2016.0183

This review of 253 referrals from primary care clinicians to dermatologists for acne measures algorithm-based treatment for the elimination of unnecessary dermatology appointments.

Effect of Ixekizumab Treatment on Work Productivity for Patients With Moderate-to-Severe Plaque Psoriasis: Analysis of Results From 3 Randomized Phase 3 Clinical Trials

April W. Armstrong, MD, MPH; Charles W. Lynde, MD, FRCP; Sandy R. McBride, MBBS, FRCP, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2016;152(6):661-669. doi:10.1001/jamadermatol.2016.0269

These 3 randomized clinical trials assess the effect of ixekizumab therapy on work productivity in adults with moderate-to-severe chronic plaque psoriasis.

Epidemiologic, Clinicopathologic, Diagnostic, and Management Challenges of Pityriasis Rubra Pilaris: A Case Series of 100 Patients

Nicholas A. Ross, MD; Hye-Jin Chung, MD; Qiaoli Li, PhD; et al.

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JAMA Dermatol. 2016;152(6):670-675. doi:10.1001/jamadermatol.2016.0091

This case series of patients with pityriasis rubra pilaris evaluates objective and subjective disease experience metrics from the perspectives of patients and clinicians.

The Role of Color and Morphologic Characteristics in Dermoscopic Diagnosis

Shirin Bajaj, BA; Michael A. Marchetti, MD; Cristian Navarrete-Dechent, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2016;152(6):676-682. doi:10.1001/jamadermatol.2016.0270

In this study, a sample of skin lesions was shown to attendees of a dermoscopy course to determine if diagnostic accuracy for common skin lesions differs between gray-scale and color dermoscopic images.

Nonmelanoma Skin Cancer With Aggressive Subclinical Extension in Immunosuppressed Patients

Silvia Soohyun Song, MD; Alina Goldenberg, MD, MAS; Arisa Ortiz, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2016;152(6):683-690. doi:10.1001/jamadermatol.2016.0192

This study reviews the clinical characteristics of nonmelanoma skin cancer with aggressive subclinical extensions (NMSC-ASE) among immunocompetent and various subgroups of immunosuppressed patients and suggests a predictive model for NMSC-ASE lesions.

Brief Report

Mucocutaneous Findings and Course in an Adult With Zika Virus Infection

Sarah M. Derrington, MD; A. Paul Cellura, MD; Laura E. McDermott, BA; et al.

Abstract Full Text

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JAMA Dermatol. 2016;152(6):691-693. doi:10.1001/jamadermatol.2016.1433

This report describes the mucocutaneous features and histologic correlation in a man returning from Puerto Rico who tested positive for the Zika virus.

Editor's Note
Zika Virus
June K. Robinson, MD

Aminolevulinic Acid Photodynamic Therapy in the Treatment of Erosive Pustular Dermatosis of the Scalp: A Case Series

Catherine S. Yang, MD; Helena Kuhn, MD; Lisa M. Cohen, MD; et al.

Abstract Full Text

JAMA Dermatol. 2016;152(6):694-697. doi:10.1001/jamadermatol.2015.6300

This case series describes on 8 patients successfully treated for erosive pustular dermatosis of the scalp with gentle curettage of the hyperkeratotic lesions followed by aminolevulinic acid photodynamic therapy.

Hair and Nail Changes During Long-term Therapy With Ibrutinib for Chronic Lymphocytic Leukemia

Carole Bitar, MD; Mohammed Z. H. Farooqui, MD; Janet Valdez, PA; et al.

Abstract Full Text

JAMA Dermatol. 2016;152(6):698-701. doi:10.1001/jamadermatol.2016.0225

This observational study assessed the incidence of brittle nails and hair changes in 66 patients with chronic lymphocytic leukemia (CLL) enrolled in a single-arm phase 2 clinical trial of ibrutinib for CLL.

Editor's Note

Zika Virus

June K. Robinson, MD

Abstract Full Text

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JAMA Dermatol. 2016;152(6):693. doi:10.1001/jamadermatol.2016.1635

Review

Cost-effectiveness of Store-and-Forward Teledermatology: A Systematic Review

Centaine Snoswell, BPharm, MPH; Anna Finnane, PhD; Monika Janda, PhD; et al.

Abstract Full Text

JAMA Dermatol. 2016;152(6):702-708. doi:10.1001/jamadermatol.2016.0525

This systematic review summarizes and evaluates the current economic evidence comparing store-and-forward teledermatology with conventional face-to-face care.

JAMA Dermatology Clinicopathological Challenge

Linear Vesicles in Newborn Resolving With Hyperpigmented Macules

José María Ortiz Salvador, MD; Lorena Martínez Leborans, MD; Altea Esteve Martínez, MD

Abstract Full Text

JAMA Dermatol. 2016;152(6):711-712. doi:10.1001/jamadermatol.2016.0095

A newborn presented with vesicular lesions over trunk and lower extremities that had begun 2 days prior; physical examination revealed vesicles filled with clear fluid disposed in a linear arrangement forming whorls and swirls. What is your diagnosis?

Blaschkoid Skin Lesions in a Young Girl

Jake E. Turrentine, MD; Katherine A. Gordon, MD; Nnenna G. Agim, MD

Abstract Full Text

JAMA Dermatol. 2016;152(6):713-714. doi:10.1001/jamadermatol.2016.0061

A young girl presented for care of skin lesions on her trunk and extremities that had been present since birth and an intermittent inflammatory reaction localized to the lesions; there was no history of developmental delay, eye abnormalities, or seizures. What is your diagnosis?

Eruptive Reddish-Yellow Coalescing Papules in the Axillae of a Middle-Aged Man

Lance W. Chapman, MD, MBA; Kristen R. Elkins, MD; Janellen Smith, MD

Abstract Full Text

JAMA Dermatol. 2016;152(6):715-716. doi:10.1001/jamadermatol.2016.0190

A 55-year-old man presented with eruptive and painless reddish-yellow papules in his axillae and endorsed polyuria and polydipsia but was otherwise asymptomatic. What is your diagnosis?

JAMA Dermatology Patient Page

Hidradenitis Suppurativa

Ali Alikhan, MD

Abstract Full Text

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JAMA Dermatol. 2016;152(6):736. doi:10.1001/jamadermatol.2016.0185

Research Letter

Association of CYP2C19 17/17 Genotype With the Risk of Voriconazole-Associated Squamous Cell Carcinoma

Kiyanna Williams, BS; Sarah T. Arron, MD, PhD

Abstract Full Text

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JAMA Dermatol. 2016;152(6):719-720. doi:10.1001/jamadermatol.2016.0351

This cohort study investigates whether lung transplant recipients with the ultrarapid-metabolizing *17 allele of CYP2C19 have an increased risk for voriconazole-associated cutaneous squamous cell carcinoma.

Patients With Psoriasis and Personalized Trade-offs in Treatment Decisions—Lessons Learned From Focus Groups

Jaehwan Kim, MD, PhD; Dong Joo Kim, MD; Francesca S. Ortenzio, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2016;152(6):720-722. doi:10.1001/jamadermatol.2016.0501

This assessment of the treatment decision-making experiences of patients with psoriasis identifies patient preferences that can be incorporated into a subsequent design of decision aids for individuals with psoriasis.

Observation

Sticky Palms Following Use of Proton-Pump Inhibitors

Salim Alkeraye, MD; Yves Baclet, MD; Emmanuel Delaporte, MD

Abstract Full Text

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JAMA Dermatol. 2016;152(6):722-723. doi:10.1001/jamadermatol.2016.0094

This case report describes 2 patients with sticky palms as an adverse effect of proton-pump inhibitors.

Rat Bite Fever Presenting As Palpable Purpura

Chase W. Kwon, BA; Kathryn Somers, MD; Glynis Scott, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2016;152(6):723-724. doi:10.1001/jamadermatol.2015.6034

This case report describes rat bite fever presenting as palpable purpura.

Anagen Effluvium Caused by Thallium Poisoning

Caren Campbell, MD; Soon Bahrami, MD; Cindy Owen, MD

Abstract Full Text

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JAMA Dermatol. 2016;152(6):724-726. doi:10.1001/jamadermatol.2016.0194

This case report describes anagen effluvium caused by thallium poisoning.

Treatment of Skin Ulcers Secondary to Sneddon Syndrome With Alprostadil (Prostaglandin E1)

Cristina Collantes-Rodríguez, MD; David Jiménez-Gallo, MD; Cintia Arjona-Aguilera, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2016;152(6):726-727. doi:10.1001/jamadermatol.2016.0162

This case report describes treatment of skin ulcers secondary to Sneddon syndrome with alprostadil (prostaglandin E1).

Unilateral Axillary Toxic Erythema of Chemotherapy in a Patient With Previous Axillary Lymph Node Dissection: Implications for Pathophysiology and Therapy

Alyssa Yeager, BA; Sasha Stephen, MD; Amy Forrestel, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2016;152(6):727-728. doi:10.1001/jamadermatol.2015.4905

This case report describes the occurrence of unilateral axillary toxic erythema of chemotherapy in a patient with previous axillary lymph node dissection.

Rumpel-Leede Phenomenon Associated With Tourniquet-like Forces of Baby Carriers in Otherwise Healthy Infants: Baby Carrier Purpura

Tuyet A. Nguyen, BS; Daniel Garcia, BS; Audrey S. Wang, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2016;152(6):728-730. doi:10.1001/jamadermatol.2015.6270

This case report describes acute-onset lower-extremity petechiae and purpura caused by dermal capillary rupture from a baby carrier in otherwise healthy infants (Rumpel-Leede phenomenon).

Notable Notes