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March 2018, Vol 154, No. 3, Pages 239-380

In This Issue of JAMA Dermatology

Highlights

Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):239. doi:10.1001/jamadermatol.2017.3823
Viewpoint

Addressing Potential Conflicts of Interest in Dermatology Clinical Practice Guidelines

Henry W. Lim, MD; Craig A. Elmets, MD; Wendy Smith Begolka, MBS
Abstract Full Text
JAMA Dermatol. 2018;154(3):259-260. doi:10.1001/jamadermatol.2017.6207

This Viewpoint discusses the importance of achieving balance between the practical and the ideal in clinical practice guideline development.

Editorial

The US Food and Drug Administration’s Approach for Safe Innovation of Medical Devices in Dermatology

Cynthia J. Chang, PhD; Binita S. Ashar, MD; Laura N. Marquart, MD
Abstract Full Text
JAMA Dermatol. 2018;154(3):261-263. doi:10.1001/jamadermatol.2017.5758

Comorbidities in Autoimmune Skin Diseases

Dennis Linder, MD, MSc; Stefano Piaserico, MD, PhD; Mauro Alaibac, MD, PhD
Abstract Full Text
JAMA Dermatol. 2018;154(3):264-265. doi:10.1001/jamadermatol.2017.5800
Original Investigation

Transparency and Dermatologic Device Approval by the US Food and Drug Administration

Harib H. Ezaldein, MD; Jeffrey F. Scott, MD; Emily S. Yin, BS; et al.
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):273-280. doi:10.1001/jamadermatol.2017.5757

This cross-sectional database study characterizes the postapproval changes to Class III dermatologic devices and evaluates inconsistencies in the use of the premarket approval pathway.

Association Between Pemphigus and Neurologic Diseases

Khalaf Kridin, MD; Shira Zelber-Sagi, PhD; Doron Comaneshter, PhD; et al.
Abstract Full Text
free access has active quiz
JAMA Dermatol. 2018;154(3):281-285. doi:10.1001/jamadermatol.2017.5799

This population-based cross-sectional study estimates the association between pemphigus and 4 neurologic conditions using one of the largest cohorts of patients with pemphigus.

Association of Psoriasis With Comorbidity Development in Children With Psoriasis

Megha M. Tollefson, MD; Holly K. Van Houten, BA; Dennis Asante, MS; et al.
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):286-292. doi:10.1001/jamadermatol.2017.5417

This cohort study examines the risk ocomorbidities in children with and without psoriasis, after accounting for obesity.

Association of Disease Severity With Skin Microbiome and Filaggrin Gene Mutations in Adult Atopic Dermatitis

Maja-Lisa Clausen, MD; Tove Agner, DMSc; Berit Lilje, PhD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):293-300. doi:10.1001/jamadermatol.2017.5440

This case-control study examines skin and nasal microbiome diversity and composition in patients with atopic dermatitis.

Combination of Follicular and Epidermal Cell Suspension as a Novel Surgical Approach in Difficult-to-Treat Vitiligo: A Randomized Clinical Trial

Muhammed Razmi T, MD, DNB; Ravinder Kumar, PhD; Seema Rani, MSc; et al.
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):301-308. doi:10.1001/jamadermatol.2017.5795

This randomized clinical trial compares the effects of combined epidermal cell suspension and follicular cell suspension with those of epidermal cell suspension alone in treatment of vitiligo.

Efficacy and Safety of Guselkumab, an Anti–interleukin 23 Monoclonal Antibody, for Palmoplantar Pustulosis: A Randomized Clinical Trial

Tadashi Terui, MD, PhD; Satomi Kobayashi, MD, PhD; Yukari Okubo, MD, PhD; et al.
Abstract Full Text
open access
JAMA Dermatol. 2018;154(3):309-316. doi:10.1001/jamadermatol.2017.5937

This randomized clinical trial evaluates the safety and efficacy of guselkumab compared with placebo for the treatment of palmoplantar pustulosis.

Opioid Prescribing Patterns and Complications in the Dermatology Medicare Population

Severine Cao, BA; Ryan Karmouta, BA; David G. Li, BS; et al.
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):317-322. doi:10.1001/jamadermatol.2017.5835

This cross-sectional study characterizes the current status and potential complications of opioid prescribing practices among dermatologists for Medicare beneficiaries.

Prevalence and Types of Genital Lesions in Organ Transplant Recipients

Kumar S. Nadhan, BS; Mary Larijani, MD; James Abbott, MD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):323-329. doi:10.1001/jamadermatol.2017.5801

This medical record review assesses the prevalence and types of genital lesions observed in organ transplant recipients.

A Novel Severity Assessment Scoring System for Hidradenitis Suppurativa

Schapoor Hessam, MD; Lisa Scholl, MD; Michael Sand, MD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):330-335. doi:10.1001/jamadermatol.2017.5890

This study examines the accuracy and clinical relevance of a newly developed scoring system for hidradenitis suppurativa severity.

Brief Report

Sun Protection Behaviors in Head Start and Other Early Childhood Education Programs in Illinois

Megan Perez, BS; Marie Donaldson, BA; Namita Jain, MD, MPH; et al.
Abstract Full Text
has audio
JAMA Dermatol. 2018;154(3):336-340. doi:10.1001/jamadermatol.2017.5257

This survey study assesses the current policies, practices, and attitudes among staff of Head Start/Early Head Start and day care centers regarding sun protection in children aged 2 to 6 years.

Early Genetic Diagnosis of Neurofibromatosis Type 2 From Skin Plaque Plexiform Schwannomas in Childhood

Elisabeth Castellanos, PhD; Adrià Plana, MD; Cristina Carrato, MD, PhD; et al.
Abstract Full Text
JAMA Dermatol. 2018;154(3):341-346. doi:10.1001/jamadermatol.2017.5464

This genetic testing study reports a case of an early diagnosis of neurofibromatosis type 2 (NF2) in a child after genetic analysis of congenital skin plaques, with confirmation of these findings by analysis of skin plaques from 6 unrelated patients with NF2.

Clinical and Immunological Profiles of 14 Patients With Bullous Pemphigoid Without IgG Autoantibodies to the BP180 NC16A Domain

Kenta Nakama, MD; Hiroshi Koga, MD; Norito Ishii, MD; et al.
Abstract Full Text
JAMA Dermatol. 2018;154(3):347-350. doi:10.1001/jamadermatol.2017.5465

This case series examines the association of nonreactivity of IgG to the noncollagenous 16A domain using the enzyme-linked immunosorbent assay and the chemiluminescent enzyme immunoassay and severity of disease course in 14 patients with bullous pemphigoid.

JAMA Dermatology Clinicopathological Challenge

Reticular Hyperpigmented Eruption in a Young Woman

Paul M. Hoesly, MD; Mark A. Cappel, MD
Abstract Full Text
JAMA Dermatol. 2018;154(3):353-354. doi:10.1001/jamadermatol.2017.4693

A woman in her 20s was seen with a 6-year history of recurrent, pruritic skin eruptions involving the middle and lower back. Physical examination showed several discrete, erythematous, scaly papules admixed with light brown reticulated macules and patches. What is your diagnosis?

Hyperpigmented Cutaneous Plaques With Ulceration on the Legs

Emma Heck, BComm; Stephanie Petkiewicz, MD; Lin Xing, MD
Abstract Full Text
JAMA Dermatol. 2018;154(3):355-356. doi:10.1001/jamadermatol.2017.4485

A woman in her 80s had a well-demarcated, oval ulcer with a violaceous, dusky border and central yellow fibrin mixed with granulation tissue and numerous violaceous to dull red, indurated plaques on the legs. What is your diagnosis?

An Annular Eruption on the Trunk and Limbs

Clara Fernández-Sartorio, MD; Llúcia Alós, MD; José M. Mascaró Jr, MD
Abstract Full Text
JAMA Dermatol. 2018;154(3):357-358. doi:10.1001/jamadermatol.2017.4320

An otherwise healthy man in his 20s presented with a 2-month history of itchy skin lesions on his trunk, arms, and groin with no associated extracutaneous symptoms. What is your diagnosis?

Research Letter

Trends in Melanoma Incidence Among Non-Hispanic Whites in the United States, 2005 to 2014

Dawn M. Holman, MPH; MaryBeth B. Freeman, MPH; Meredith L. Shoemaker, MPH
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):361-362. doi:10.1001/jamadermatol.2017.5541

This analysis examines data from 2 major databases on melanoma incidence trends among the non-Hispanic white population in the United States by 10-year age groups.

Variable Response to Naltrexone in Patients With Hailey-Hailey Disease

Severine Cao, BA; Evelyn Lilly, MD; Steven T. Chen, MD, MPH
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):362-363. doi:10.1001/jamadermatol.2017.5463

This case series presents 3 cases of patients with Hailey-Hailey disease demonstrating varying responses to naltrexone.

Rituximab as Single Long-term Maintenance Therapy in Patients With Difficult-to-Treat Pemphigus

Julia Sanchez, MD; Saskia Ingen-Housz-Oro, MD; Olivier Chosidow, MD, PhD; et al.
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):363-365. doi:10.1001/jamadermatol.2017.5176

This case-series study of 11 patients with severe, difficult-to-treat pemphigus examines whether rituximab alone can be used long-term as maintenance therapy for prevention of relapse.

Association of Facial Exercise With the Appearance of Aging

Murad Alam, MD, MSCI, MBA; Anne J. Walter, MD, MBA; Amelia Geisler, BS; et al.
Abstract Full Text
free access
JAMA Dermatol. 2018;154(3):365-367. doi:10.1001/jamadermatol.2017.5142

This pilot study assesses the association of a 20-week facial exercise program with the facial appearance of middle-aged women.

Observation

Generalized Lichen Nitidus Following Anti–PD-1 Antibody Treatment

Maria Cho, MBBS; Yumi Nonomura, MD, PhD; Yo Kaku, MD; et al.
Abstract Full Text
JAMA Dermatol. 2018;154(3):367-369. doi:10.1001/jamadermatol.2017.5670

This case report describes the occurrence of generalized lichen nitidus following anti–PD-1 antibody treatment.

Erythema Nodosum–like Eruption in the Setting of Sorafenib Therapy

Emily L. Coleman, BA; Shawn E. Cowper, MD; Stacey M. Stein, MD; et al.
Abstract Full Text
JAMA Dermatol. 2018;154(3):369-370. doi:10.1001/jamadermatol.2017.5733

This case report describes a patient with erythema nodosum–like eruption in the setting of sorafenib therapy.

Rapid Repigmentation of Vitiligo Using Tofacitinib Plus Low-Dose, Narrowband UV-B Phototherapy

Sa Rang Kim, BSc; Henry Heaton, MD; Lucy Y. Liu, BA; et al.
Abstract Full Text
JAMA Dermatol. 2018;154(3):370-371. doi:10.1001/jamadermatol.2017.5778

This case report describes 2 patients who experienced rapid repigmentation of vitiligo-affected skin after tofacitinib plus low-dose, narrowband UV-B therapy.

Bosentan for Cutaneous Ulcers in Anti-MDA5 Dermatomyositis

Andrea Combalia, MD; Priscila Giavedoni, MD; Lorena Tamez, MD; et al.
Abstract Full Text
JAMA Dermatol. 2018;154(3):371-373. doi:10.1001/jamadermatol.2017.5462

This case report describes the use of bosentan for treatment of cutaneous ulcers in a patient with anti-MDA5 dermatomyositis.

Comment & Response

Evaluating Industry Payments Among Dermatology Clinical Practice Guideline Authors

Alex M. Glazer, MD; Daniel M. Siegel, MD, MS; Darrell S. Rigel, MD, MS
Abstract Full Text
JAMA Dermatol. 2018;154(3):373-374. doi:10.1001/jamadermatol.2017.6209

Evaluating Industry Payments Among Dermatology Clinical Practice Guideline Authors—Reply

Jake Xavier Checketts, BS; Matt Vassar, PhD
Abstract Full Text
JAMA Dermatol. 2018;154(3):374-375. doi:10.1001/jamadermatol.2017.6208
Notable Notes

The History of Congenital Syphilis Behind The Inheritance by Edvard Munch

Antonio Perciaccante, MD; Alessia Coralli, BSN
Abstract Full Text
JAMA Dermatol. 2018;154(3):280. doi:10.1001/jamadermatol.2017.5834

Filippo Pacini—A Life of Achievement

Aria Shakeri, HBSc
Abstract Full Text
JAMA Dermatol. 2018;154(3):300. doi:10.1001/jamadermatol.2017.5356

Monroe’s Mark

Tyler Marion, BS, MBA; Kevin Cao, BS; Jorge Roman, MD
Abstract Full Text
JAMA Dermatol. 2018;154(3):308. doi:10.1001/jamadermatol.2017.5756

The “Moon Face” of Cushing Syndrome

Leonard J. Hoenig, MD
Abstract Full Text
JAMA Dermatol. 2018;154(3):329. doi:10.1001/jamadermatol.2017.5798

Sir James Paget—Contributions of a Surgeon and Pathologist

Manthan Patel, MS; Varun Ayyaswami, BS; Arpan V. Prabhu, BS
Abstract Full Text
JAMA Dermatol. 2018;154(3):335. doi:10.1001/jamadermatol.2017.6127

A Thousand Words

Kevin Cao, BS; Tyler Marion, BS, MBA; Jorge Roman, MD
Abstract Full Text
JAMA Dermatol. 2018;154(3):375. doi:10.1001/jamadermatol.2017.5355
JAMA Dermatology Patient Page

Sun Safety

June K. Robinson, MD
Abstract Full Text
free access has audio
JAMA Dermatol. 2018;154(3):380. doi:10.1001/jamadermatol.2017.5256

This Patient Page provides information on sun protection and safety.

JAMA Dermatology Masthead

JAMA Dermatology

Abstract Full Text
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JAMA Dermatol. 2018;154(3):253. doi:10.1001/jamadermatol.2017.3824
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