July 2018, Vol 154, No. 7, Pages 747-852

In This Issue of JAMA Dermatology

Highlights

Abstract Full Text

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JAMA Dermatol. 2018;154(7):747. doi:10.1001/jamadermatol.2017.3843

Viewpoint

Reevaluating Mohs Surgery Appropriate Use Criteria for Primary Superficial Basal Cell Carcinoma

Howard K. Steinman, MD; Anthony Dixon, PhD, MBBS; Christopher B. Zachary, MBBS, FRCP

Abstract Full Text

JAMA Dermatol. 2018;154(7):755-756. doi:10.1001/jamadermatol.2018.0111

This Viewpoint discusses the process of reevaluating Mohs surgery appropriate use criteria for primary superficial basal cell carcinoma.

Geriatric Dermatology—A Framework for Caring for Older Patients With Skin Disease

Eleni Linos, MD, MPH, DrPH; Mary-Margaret Chren, MD; Ken Covinsky, MD

Abstract Full Text

JAMA Dermatol. 2018;154(7):757-758. doi:10.1001/jamadermatol.2018.0286

This Viewpoint describes principles of geriatric science that allow for more appropriate dermatological care for the US population of patients older than 65 years.

Editorial

The Future of JAMA Dermatology

Kanade Shinkai, MD, PhD

Abstract Full Text

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JAMA Dermatol. 2018;154(7):759-760. doi:10.1001/jamadermatol.2018.1997

Topical Sirolimus to Treat Tuberous Sclerosis Complex (TSC)

Thomas N. Darling, MD, PhD

Abstract Full Text

JAMA Dermatol. 2018;154(7):761-762. doi:10.1001/jamadermatol.2018.0465

Update on Emergency and Nonemergency Use of Hyaluronidase in Aesthetic Dermatology

Derek H. Jones, MD

Abstract Full Text

JAMA Dermatol. 2018;154(7):763-764. doi:10.1001/jamadermatol.2018.0516

Original Investigation

Effectiveness of Low Doses of Hyaluronidase to Remove Hyaluronic Acid Filler Nodules: A Randomized Clinical Trial

Murad Alam, MD, MSCI, MBA; Rosemara Hughart, MD; Amelia Geisler, BS; et al.

Abstract Full Text

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JAMA Dermatol. 2018;154(7):765-772. doi:10.1001/jamadermatol.2018.0515

This parallel-group, randomized clinical trial assesses the effectiveness and dose-related effect of small quantities of hyaluronidase vs saline to treat hyaluronic acid filler nodules in healthy women.

Efficacy and Safety of Topical Rapamycin in Patients With Facial Angiofibromas Secondary to Tuberous Sclerosis Complex: The TREATMENT Randomized Clinical Trial

Mary Kay Koenig, MD; Cynthia S. Bell, MS; Adelaide A. Hebert, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2018;154(7):773-780. doi:10.1001/jamadermatol.2018.0464

This randomized clinical trial examines the efficacy and safety of topical rapamycin therapy for treatment of patients with tuberous sclerosis complex–related facial angiofibromas.

Audio Author Interview: Topical Rapamycin in Patients With Facial Angiofibromas

Sirolimus Gel Treatment vs Placebo for Facial Angiofibromas in Patients With Tuberous Sclerosis Complex: A Randomized Clinical Trial

Mari Wataya-Kaneda, MD, PhD; Yuuki Ohno, MD; Yasuyuki Fujita, MD, PhD; et al.

Abstract Full Text

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JAMA Dermatol. 2018;154(7):781-788. doi:10.1001/jamadermatol.2018.1408

This randomized clinical trial assesses the efficacy and safety of sirolimus gel, 0.2% vs placebo for treatment of angiofibromas and skin lesions in adult and pediatric patients with tuberous sclerosis complex.

Contributions by MC1R Variants to Melanoma Risk in Males and Females

Judith Wendt, MD, PhD; Christoph Mueller, MD; Sabine Rauscher, MSc; et al.

Abstract Full Text

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JAMA Dermatol. 2018;154(7):789-795. doi:10.1001/jamadermatol.2018.1252

This case-control study evaluates the association of melanocortin-1-receptor (MC1R) with melanoma risk in males vs females, adjusting for risk factors such as age, pigmentation, phenotype, signs of skin damage, and sun exposure.

Whole-Body Distribution and Clinical Association of Telangiectases in Systemic Sclerosis

Mathieu Jouvray, MD; David Launay, MD, PhD; Sylvain Dubucquoi, MD, PhD; et al.

Abstract Full Text

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JAMA Dermatol. 2018;154(7):796-805. doi:10.1001/jamadermatol.2018.0916

This cross-sectional study evaluates the association between the presence and distribution of telangiectases and the severity of vasculopathy in patients with systemic sclerosis.

Efficacy and Safety of Ozenoxacin Cream for Treatment of Adult and Pediatric Patients With Impetigo: A Randomized Clinical Trial

Theodore Rosen, MD; Nuria Albareda, BS; Noah Rosenberg, MD; et al.

Abstract Full Text

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JAMA Dermatol. 2018;154(7):806-813. doi:10.1001/jamadermatol.2018.1103

This randomized clinical trial evaluates the efficacy, safety, and tolerability of ozenoxacin cream vs placebo in children and adults with impetigo.

Overall and Subgroup Prevalence of Crohn Disease Among Patients With Hidradenitis Suppurativa: A Population-Based Analysis in the United States

Amit Garg, MD; Jessica Hundal, BA; Andrew Strunk, MA

Abstract Full Text

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JAMA Dermatol. 2018;154(7):814-818. doi:10.1001/jamadermatol.2018.0878

This cross-sectional cohort analysis of electronic health records from a large US database evaluates overall and subgroup prevalence of Crohn disease among patients with hidradenitis suppurativa.

Brief Report

Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus–Associated Vulvar Squamous Cell Carcinoma

John Charles Rotondo, PhD; Alessandro Borghi, MD; Rita Selvatici, PhD; et al.

Abstract Full Text

JAMA Dermatol. 2018;154(7):819-823. doi:10.1001/jamadermatol.2018.1373

This case-control study examines the association of retinoic acid receptor β tumor-suppressor gene with the onset and progression of lichen sclerosus–associated vulvar squamous cell carcinoma.

Adolescents’ Perspectives on Atopic Dermatitis Treatment—Experiences, Preferences, and Beliefs

Richelle C. Kosse, MSc; Marcel L. Bouvy, PhD, PharmD; Maud Daanen, BSc; et al.

Abstract Full Text

JAMA Dermatol. 2018;154(7):824-827. doi:10.1001/jamadermatol.2018.1096

This qualitative study examines the beliefs, experiences, and preferences of adolescents with atopic dermatitis toward their treatment via focus groups interviews.

Hemophagocytic Lymphohistiocytosis in Cutaneous T-Cell Lymphoma

Dylan E. Lee, BS; M. Estela Martinez-Escala, MD, PhD; Linda M. Serrano, MD; et al.

Abstract Full Text

JAMA Dermatol. 2018;154(7):828-831. doi:10.1001/jamadermatol.2018.1264

This case series examines the characteristics of cutaneous T-cell lymphoma associated with hemophagocytic lymphohistiocytosis and analyzes the presenting signs and symptoms, therapeutic options, and outcomes.

JAMA Dermatology Clinicopathological Challenge

Urticaria and Episcleritis in a Woman With Chronic Cough

Christina Dai, BA; David Weinstein, MD

Abstract Full Text

JAMA Dermatol. 2018;154(7):833-834. doi:10.1001/jamadermatol.2017.6134

A woman in her 30s presented with a 10-month history of painful pruritic eruption and painful red eyes; the eruption was exacerbated by stress but unrelated to time of day, ambient temperature, or sunlight exposure. She also reported recent worsening of a chronic cough. What is your diagnosis?

Disseminated Asymptomatic Papules Over the Body

Ruojun Wang, MD; Zhimiao Lin, MD

Abstract Full Text

JAMA Dermatol. 2018;154(7):835-836. doi:10.1001/jamadermatol.2017.6054

A woman in her 30s had a 15-year history of generalized asymptomatic papules on her arms, trunk, legs, neck, and face; examination revealed skin-colored to red-brown papules distributed over her trunk, extremities, neck, forehead, and periocular regions. What is your diagnosis?

Solitary Asymptomatic Tumor in the Axilla

Konstantin Dumann, MD; Jan C. Simon, MD; Mirjana Ziemer, MD

Abstract Full Text

JAMA Dermatol. 2018;154(7):837-838. doi:10.1001/jamadermatol.2017.5976

A woman in her 60s presented with a solitary, indolent, erythematous plaque in the right axilla and also reported a slowly growing subcutaneous node with progressive infiltration of the overlying skin. What is your diagnosis?

Research Letter

Prevalence of Skin Cancer Examination Among Users of Indoor Tanning Beds

Kasey L. Morris, PhD; Markham C. Luke, MD, PhD; Frank M. Perna, EdD, PhD

Abstract Full Text

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JAMA Dermatol. 2018;154(7):840-842. doi:10.1001/jamadermatol.2018.1118

This study uses weighted national survey data to examine the prevalence of skin cancer examinations among users of indoor tanning beds.

Sun Protection Among Organ Transplant Recipients After Participation in a Skin Cancer Research Study

Rebecca I. Hartman, MD, MPH; Adele C. Green, MBBS, PhD; Louisa G. Gordon, PhD; et al.

Abstract Full Text

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JAMA Dermatol. 2018;154(7):842-844. doi:10.1001/jamadermatol.2018.1164

This study investigates the use of sun protection among organ transplant recipients after participation in a skin cancer research study.

Demographic, Academic, and Publication Factors Associated With Academic Dermatology Career Selection

Connie R. Shi, BS; Joe K. Tung, BS; Vinod E. Nambudiri, MD, MBA

Abstract Full Text

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JAMA Dermatol. 2018;154(7):844-846. doi:10.1001/jamadermatol.2018.0743

This cohort study examines associations between demographic, academic, and publication factors and dermatology trainees’ initial choice of academic vs private practice careers.

Observation

Cutaneous Eruption Secondary to Immunotherapy for Metastatic Melanoma Limited to Sites of Locoregional Melanoma Metastases: A Possible Variant of Locus Minoris Resistentiae

Marie Donaldson, BA; Joshua L. Owen, MD, PhD; Jennifer N. Choi, MD

Abstract Full Text

JAMA Dermatol. 2018;154(7):846-847. doi:10.1001/jamadermatol.2018.0654

This case report describes 2 patients with cutaneous eruptions secondary to immunotherapy for metastatic melanoma limited to sites of locoregional melanoma metastases.