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November 2021 - January 1920




November 2021, Vol 157, No. 11, Pages 1262-1384


Targeting Immune Checkpoints and Cytokines to Protect From Psoriasis Relapse

Abstract Full Text
JAMA Dermatol. 2021;157(11):1269-1271. doi:10.1001/jamadermatol.2021.3491

Risk of Bias and Error From Data Sets Used for Dermatologic Artificial Intelligence

Abstract Full Text
JAMA Dermatol. 2021;157(11):1271-1273. doi:10.1001/jamadermatol.2021.3128
Original Investigation

Efficacy and Safety of Bimekizumab in Moderate to Severe Hidradenitis Suppurativa: A Phase 2, Double-blind, Placebo-Controlled Randomized Clinical Trial

Abstract Full Text
open access
JAMA Dermatol. 2021;157(11):1279-1288. doi:10.1001/jamadermatol.2021.2905

This randomized clinical trial assesses whether bimekizumab is efficacious and safe when used to treat patients with hidradenitis suppurativa.

Sirolimus (Rapamycin) for Slow-Flow Malformations in Children: The Observational-Phase Randomized Clinical PERFORMUS Trial

Abstract Full Text
JAMA Dermatol. 2021;157(11):1289-1298. doi:10.1001/jamadermatol.2021.3459

This randomized clinical trial assesses the efficacy and safety of sirolimus among children with slow-flow vascular malformations to better delineate the indications for treatment.

Rates of Opioid Prescriptions Obtained After Mohs Surgery: A Claims Database Analysis From 2009 to 2020

Abstract Full Text
JAMA Dermatol. 2021;157(11):1299-1305. doi:10.1001/jamadermatol.2021.3468

This cross-sectional study characterizes the frequency and changes over time (2009-2020) of opioid prescriptions following Mohs micrographic surgery.

Effect of Costimulatory Blockade With Abatacept After Ustekinumab Withdrawal in Patients With Moderate to Severe Plaque Psoriasis: The PAUSE Randomized Clinical Trial

Abstract Full Text
open access
JAMA Dermatol. 2021;157(11):1306-1315. doi:10.1001/jamadermatol.2021.3492

This parallel-design, double-blind randomized clinical trial evaluates whether abatacept could prevent psoriasis relapse after discontinuation of ustekinumab treatment in adults with plaque psoriasis.

Evaluation of Pharmacologic Treatments for H1 Antihistamine–Refractory Chronic Spontaneous Urticaria: A Systematic Review and Network Meta-analysis

Abstract Full Text
has active quiz
JAMA Dermatol. 2021;157(11):1316-1327. doi:10.1001/jamadermatol.2021.3237

This network meta-analysis examines the effects of H1 antihistamines reported in randomized clinical trials for treatment in patients with chronic spontaneous urticaria.

Mapping of Segmental and Partial Segmental Infantile Hemangiomas of the Face and Scalp

Abstract Full Text
JAMA Dermatol. 2021;157(11):1328-1334. doi:10.1001/jamadermatol.2021.3479

This cohort study aims to refine previous maps defining the distribution of facial segment hemangiomas and determine whether patterns of indeterminate hemangiomas are related to their segmental counterparts.

Clinicopathologic Characteristics and Response to Treatment of Persistent Chemotherapy-Induced Alopecia in Breast Cancer Survivors

Abstract Full Text
JAMA Dermatol. 2021;157(11):1335-1342. doi:10.1001/jamadermatol.2021.3676

This case series analyzes the clinicopathologic characteristics and response to treatment of patients with persistent chemotherapy-induced alopecia after chemotherapy for breast cancer.

Assessment of Clinical and Laboratory Use of the Cutaneous Direct Immunofluorescence Assay

Abstract Full Text
JAMA Dermatol. 2021;157(11):1343-1348. doi:10.1001/jamadermatol.2021.3892

This quality improvement study examines the need for specific vs full-panel antibody testing in patients with skin diseases.

Brief Report

UBA1 Variations in Neutrophilic Dermatosis Skin Lesions of Patients With VEXAS Syndrome

Abstract Full Text
JAMA Dermatol. 2021;157(11):1349-1354. doi:10.1001/jamadermatol.2021.3344

This case series study of 8 French men examines clinical and pathological skin manifestations and their pathophysiology in VEXAS syndrome.

Inflation-Adjusted Trends in Medicare Reimbursement for Common Dermatologic Procedures, 2007-2021

Abstract Full Text
JAMA Dermatol. 2021;157(11):1355-1358. doi:10.1001/jamadermatol.2021.3453

This cross-sectional study identifies trends in Medicare reimbursement for 46 common dermatologic procedures from 2007 to 2021.


Lack of Transparency and Potential Bias in Artificial Intelligence Data Sets and Algorithms: A Scoping Review

Abstract Full Text
has audio
JAMA Dermatol. 2021;157(11):1362-1369. doi:10.1001/jamadermatol.2021.3129

This scoping review analyzes the literature on algorithms assessing skin disease for data set criteria, emphasizing transparency and concerns about bias.

Images in Dermatology

Cutaneous Lupus Erythematosus of the Vulvar Skin

Abstract Full Text
JAMA Dermatol. 2021;157(11):1370. doi:10.1001/jamadermatol.2021.3293

This case report describes scarred erythematous patches on the labia majora, labia minora, and inguinal folds with no mucosal involvement.

Minute Acral Melanoma

Abstract Full Text
JAMA Dermatol. 2021;157(11):1371. doi:10.1001/jamadermatol.2021.3298

This case report describes a homogeneously pigmented spot on the patient’s right sole and a parallel ridge pattern without asymmetry of colors and structures.

JAMA Dermatology Clinicopathological Challenge

Widespread Erythematous Plaques With Prominent Telangiectases

Abstract Full Text
has active quiz
JAMA Dermatol. 2021;157(11):1376-1377. doi:10.1001/jamadermatol.2021.4068

A woman in her 50s with a history of nasal-type natural killer/T-cell lymphoma and chronic pulmonary coccidiomycosis was admitted for fever, hypotension, and asymptomatic widespread rash. What is your diagnosis?

Research Letter

Prevalence and Characterization of Itch in Pachyonychia Congenita

Abstract Full Text
JAMA Dermatol. 2021;157(11):1378-1380. doi:10.1001/jamadermatol.2021.3335

This survey study examines the prevalence and characteristics of itch in pachyonychia congenita.


Improvement of Chronic Kidney Disease–Associated Pruritus After Treatment With Intravenous Naloxone

Abstract Full Text
JAMA Dermatol. 2021;157(11):1380-1381. doi:10.1001/jamadermatol.2021.3829

This case report examines whether the use of naloxone has an antipruritic effect in patients with chronic kidney disease–associated pruritus.

Evaluation and Treatment of Febrile Ulceronecrotic Mucha-Habermann Disease With Ruxolitinib and Tocilizumab as Guided by Cytokine Profile

Abstract Full Text
JAMA Dermatol. 2021;157(11):1381-1383. doi:10.1001/jamadermatol.2021.4047

This case report describes treatment with tocilizumab and ruxolitinib for febrile ulceronecrotic Mucha-Habermann disease.

Comment & Response

What Are We Waiting for?—Start Screening High-risk Individuals for Anal Cancer Now

Abstract Full Text
JAMA Dermatol. 2021;157(11):1383-1384. doi:10.1001/jamadermatol.2021.3832

What Are We Waiting for?—Start Screening High-risk Individuals for Anal Cancer Now—Reply

Abstract Full Text
JAMA Dermatol. 2021;157(11):1384. doi:10.1001/jamadermatol.2021.3415

Errors in Abstract, Key Points, Figures, and a Table

Abstract Full Text
free access
JAMA Dermatol. 2021;157(11):1384. doi:10.1001/jamadermatol.2021.4442
JAMA Dermatology Masthead

JAMA Dermatology

Abstract Full Text
free access
JAMA Dermatol. 2021;157(11):1262. doi:10.1001/jamadermatol.2020.3914