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Editor's Correspondence
Nov/Dec 2012

Inability of Speculation to Explain Dose Effect Differences Between Botulinum Toxin Products

Author Affiliations

Author Affiliations: Toxin Science Ltd, Wrexham, Wales, United Kingdom, and Botulinum Research Center, University of Dartmouth, Dartmouth, Massachusetts.

Arch Facial Plast Surg. 2012;14(6):467-468. doi:10.1001/jamafacial.2013.366

The recent publication from Yu et al,1 examining 2 botulinum toxin products for the treatment of lateral orbital rhytids, shows an apparent clinical distinction between the products. AbobotulinumtoxinA (Dysport; Medicis) demonstrated a trend toward greater improvement at day 2 and statistically significant improvements at days 4 and 6, all at maximum contraction.1 This report seems to be almost a duplicate of that previously published by the same group,2 but the number of injection points has been reduced from 5 to 4 in the later report.1 The 2 studies seem to be part of the same trial.1

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