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Invited Commentary
Jul/Aug 2015

Furthering the Understanding of Actions of Botulinum Toxin A

Author Affiliations
  • 1Indiana University School of Medicine, Bloomington
JAMA Facial Plast Surg. 2015;17(4):263-264. doi:10.1001/jamafacial.2015.0567

The fountain of youth or potent neurotoxin? Botulinum toxin represents both. It has long been known that victims of facial paralysis present a more youthful visage on the paralyzed side, and minimizing muscular contractions can help prevent the formation of folds and rhytids in facial skin. The biochemical impact of muscular contractions, however, has largely been overlooked and represents a fascinating new field in the understanding of the aging process. That injections affect far more than muscular contraction, and actually improve collagen and skin quality, is just now being investigated as a valid histologic response.