There are 2 potential oversights in the comprehensive article by Dalen et al1 that I wish to bring to the authors' attention. Dalen et al argue that for thrombolytic therapy to reduce mortality,
it would have to result in a very rapid resolution of pulmonary embolic obstruction in patients with shock due to massive PE [pulmonary embolism], or it would have to prevent or reduce the incidence of recurrent PE.
Workman S. Thrombolytic Therapy for Pulmonary Embolism. Arch Intern Med. 1998;158(15):1716. doi:
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