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Editor's Correspondence
August 9/23, 2010

Does Methadone Prolong QTc Intervals by Depleting Testosterone Levels?

Author Affiliations

Author Affiliation: Dr Daniell is in private practice in Redding, California.

Arch Intern Med. 2010;170(15):1407-1408. doi:10.1001/archinternmed.2010.282

Ansermot et al1 have suggested the possibility that (R)-methadone can be substituted for (R,S)-methadone in clinical practice to decrease methadone-induced prolongation of corrected QT (QTc) intervals, thereby lowering the risk of torsades de pointes. Multiple observations indicate that this recommendation should only be considered after exploring the possibility of a relationship between QTc intervals and testosterone levels in men receiving methadone.

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