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Editor's Correspondence
September 12, 2009

Vitamin D Supplements vs Plasma Level—Reply

Arch Intern Med. 2009;169(16):1536-1537. doi:10.1001/archinternmed.2009.281

In reply

In a previous issue of the Archives, Giovannucci et al1 linked higher vitamin D levels to lower cardiac risk. We surmised that the “contradictory” neutral finding for vitamin D + calcium supplementation (calcium carbonate, 500 mg as elemental calcium, with cholecalciferol [vitamin D3], 200 IU twice daily) against myocardial infarction (MI) risk in the large WHI trial2 might be speculated to arise from benefits of vitamin D against MI risk being offset by harms arising from the calcium with which it was given.3

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