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Clinical Observation
August 10, 2009

Heparin Treatment for Severe Hypertriglyceridemia in Diabetic Ketoacidosis

Author Affiliations

Author Affiliation: Department of Medicine, Holy Name Hospital, Teaneck, New Jersey.

Arch Intern Med. 2009;169(15):1439-1441. doi:10.1001/archinternmed.2009.221

In a patient with diabetic ketoacidosis complicated by severe elevation of plasma triglyceride concentrations, treatment with low-level intravenous unfractionated heparin led to prompt reduction in plasma triglyceride concentration and may have prevented the development of hypertriglyceridemia-associated acute pancreatitis. This article reviews the rationale for this treatment and surveys prior publications using heparin in this and similar settings.

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