In reply
The first remark by Yazdanpanah et al applied the undiagnosed-infection prevalence observed in the metropolitan Paris emergency departments (EDs) (0.14%) to all persons aged 18 to 64 years in France and claimed that national undetected human immunodeficiency virus (HIV) infections reach 56 000. Because the number of diagnoses per Paris-area inhabitant is 4 times higher than in other regions, that calculation largely overestimates the national prevalence. We would rather conclude that the undiagnosed infection prevalence in France is far below the Centers for Disease Control and Prevention–recommended 0.10% threshold for performing nontargeted screening.1