Author Affiliations: Geriatrics Unit, S Antonio Hospital, Padova, Italy (Dr Pilotto); Geriatric Unit and Gerontology–Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy (Drs Pilotto and Panza); and Clinical Research Branch, National Institute on Aging, Baltimore, Maryland (Dr Ferrucci).
We read with interest the study of Siontis and colleagues,1 which reported that, during 2009, among 118 different clinical prediction rules (CPRs) designed to estimate the risk of all-cause mortality, only 10 were studied in 4 or more separate groups of patients, and of these, only 1 CPR was reasonably accurate across all studies.1 Among the 118 CPRs selected for this study, there was also the Multidimensional Prognostic Index (MPI), derived from a standardized Comprehensive Geriatric Assessment, and developed and validated in 2 independent cohorts of older patients hospitalized for acute disease or relapse of a chronic disease, with a close agreement between the estimated and the observed mortality after both 6 months and 1 year of follow-up.2
Pilotto A, Panza F, Ferrucci L. A Multidimensional Prognostic Index in Common Conditions Leading to Death in Older Patients. Arch Intern Med. 2012;172(7):595–596. doi:10.1001/archinternmed.2011.1891