In studying the hypercholesterinemia of cholelithiasis, a group of patients was encountered who had a continuous hypercholesterinemia.1 Even after operation, at which all causes for an obstructive hypercholesterinemia were removed, these patients again became hypercholesterinemic with no discoverable basis for this condition.
In work previously published2 we gave the evidence for believing that the liver is the regulator of the cholesterol metabolism of the body, the cholesterol being kept at a more or less constant level by excretion of cholesterol through the bile. It is of interest, therefore, to ascertain the cholesterol content of the blood of patients with various disorders of the liver usually associated with icterus.
In obstructive icterus due to cholelithiasis, we have almost invariably encountered a hypercholesterinemia of a rather severe grade. The amounts in the blood varied from 700 mg. to 250 mg. per 100 c.c. The degree of jaundice bore a definite relation to
ROTHSCHILD MA, FELSEN J. THE CHOLESTEROL CONTENT OF THE BLOOD IN VARIOUS HEPATIC CONDITIONS. Arch Intern Med (Chic). 1919;24(5):520–522. doi:10.1001/archinte.1919.00090280051006
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: