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Editor's Correspondence
May 9, 2005

Confounders of Uric Acid Levels

Arch Intern Med. 2005;165(9):1071. doi:10.1001/archinte.165.9.1071-a

Niskanen and colleagues1 recently demonstrated that uric acid (UA) levels were a significant independent predictor of cardiovascular disease (CVD) mortality in healthy middle-aged men after comprehensive assessment and adjustment for variables associated with the gout or metabolic syndrome. However, they do not address the individual categories of alcoholic beverages, the incident cases of gout during the long-term follow-up, and the effect of initiating UA-lowering pharmacotherapy for men at the second tertile (UA level, 5.05-5.88 mg/dL [300.37-349.74 μmol/L]), all of whom had normal UA levels below 7 mg/dL (<416.36 μmol/L).2

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