Adolescent and Adult Pharyngitis: More Than “Strep Throat”: Comment on “Large-Scale Validation of the Centor and McIsaac Scores to Predict Group A Streptococcal Pharyngitis”

In this issue of the Archives, Fine and colleagues¹ report a major validation of clinical prediction rules for predicting group A streptococcal (GAS) pharyngitis. They examine the prediction model that I and my research team² first reported in 1981 and the modification (incorporating age into the decision rule) that McIsaac et al³ reported in 1998. This validation confirms a recent meta-analysis that arrived at the same finding.⁴