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Editor's Correspondence
May 28, 2012

Dabigatran and Myocardial Infarction: Meta-Illusion?

Author Affiliations

Author Affiliations: School of Medicine and Public Health, Salvador, Brazil (Dr Correia); and School of Medicine, Federal University of Bahia, Bahia, Brazil (Dr Lopes).

Arch Intern Med. 2012;172(10):823-823. doi:10.1001/archinternmed.2012.836

We read with great interest the article by Uchino and Hernandez.1 By performing a meta-analysis of 7 randomized trials, they suggested that dabigatran therapy is associated with increased risk of myocardial infarction (MI) or acute coronary syndrome (ACS). Even though meta-analyses provide strong evidence for efficacy and safety, the role of chance should always be taken into account before definite conclusions.