In a small (n = 53), 12-month, randomized controlled trial, Hajjar et al1 found that elderly hypertensive subjects with impaired executive functioning showed greater executive improvements with candesartan (an angiotensin receptor blocker [ARB]) therapy than with lisinopril or hydrochlorothiazide. They concluded that cognitive protection may arise through selectivity of angiotensin receptor blockade with ARBs.