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Invited Commentary
Oct 8, 2012

Perfluorooctanoic Acid Exposure and Cardiovascular Disease: Potential Role and Preventive Measures
Comment on “Perfluorooctanoic Acid and Cardiovascular Disease in US Adults”

Author Affiliations

Author Affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso.

Arch Intern Med. 2012;172(18):1403-1405. doi:10.1001/archinternmed.2012.3397

Cardiovascular disease (CVD) remains the most common cause of morbidity and mortality in the United States. In 2008, the overall rate of deaths attributable to CVD was 244.8 per 100 000,1 and currently more than 2200 Americans die of CVD each day, an average of 1 death every 39 seconds.1 Although the large case-control study Effect of Potentially Modifiable Risk Factors Associated With Myocardial Infarction in 52 Countries (INTERHEART) suggested that lipid levels; smoking; hypertension; diabetes mellitus; abdominal obesity; psychosocial factors; consumption of fruits, vegetables, and alcohol; and degree of physical activity account for most (approximately 90%) of the risk for myocardial infarction worldwide in both sexes and at all ages in all regions,2 other novel risk factors may also play a role.

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