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Editor's Correspondence
Oct 8, 2012

Antipsychotic Drugs and Myocardial Infarction in Patients With Dementia

Author Affiliations

Author Affiliations: Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bangalore India (Dr Andrade); and Department of Psychiatry, Creighton University School of Medicine, Omaha, Nebraska (Dr Fernandes).

Arch Intern Med. 2012;172(18):1428-1429. doi:10.1001/archinternmed.2012.3761

Pariente et al1 conducted a retrospective study of prescription claims data and found that, in elderly patients receiving anticholinesterase medications, antipsychotic dispensing was associated with an increased risk of myocardial infarction only during the first 2 months following antipsychotic initiation; in matched cohort and self-controlled analyses, there was no statistically significant elevation in infarction risk during subsequent periods, extending to a year after antipsychotic initiation and beyond.