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Invited Commentary
April 8, 2013

Reversing Gears: Discontinuing Medication Therapy to Prevent Adverse EventsComment on “Proton Pump Inhibitors and Risk of 1-Year Mortality and Rehospitalization in Older Patients Discharged From Acute Care Hospitals”

JAMA Intern Med. 2013;173(7):524-525. doi:10.1001/jamainternmed.2013.4068

Proton pump inhibitors (PPIs) are a class of medications used to suppress production of gastric acid, and indications for their use include the treatment of dyspepsia, gastroesophageal reflux disease, and gastric and duodenal ulcers. Proton pump inhibitors are also recommended for hospitalized patients in intensive care unit settings for prophylaxis of stress ulcers. In the short term, PPIs are quite effective at symptom relief and treatment of these acid-related conditions; however, no recommendations have been made for the frequently observed prophylactic use of PPIs in nonintensive medical and surgical inpatient settings. Although indications exist for long-term therapy (eg, hypersecretory states), long-term use is often not warranted.1