The Ability of a Retrospective Review of Electronic Health Records to Fully Capture the Frequency of Supratherapeutic Dosing of Acetaminophen—Reply

In reply

Dr Charpiat raises valid points. A tendency to underestimate the rate of supratherapeutic dosing would be driven by the proportion of patients studied who were underweight, which we did not measure.¹ Weight-based dosing is widely used in children younger than 12 years, but not in the adult population we studied.² However, we did perform secondary analyses for elderly patients and patients with chronic liver disease, who may be at increased risk of toxic effects from acetaminophen use or have lower therapeutic windows.