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Invited Commentary
September 9, 2013

Challenges in Treating Prosthetic Valve Endocarditis

Author Affiliations
  • 1Department of Medicine, University of California, San Francisco
JAMA Intern Med. 2013;173(16):1504-1505. doi:10.1001/jamainternmed.2013.7020

Which patients with endocarditis will benefit from early surgery is vigorously debated. Prospective randomized trials have demonstrated that patients with infections of native mitral and aortic valves associated with large vegetations and severe valvular regurgitation benefit from early surgery in terms of longer survival and fewer embolic complications1; several observational studies2,3 using propensity score analysis have also supported early surgery in high-risk patients.

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