IN THE IDEAL WORLD, the practice of medicine would be entirely evidence based, with decisions on how to use new medications being based on well-designed, double-blind, placebo-controlled studies. One need not look further than the multibillion dollar nutritional-supplement and "natural-treatments" market to know that a considerable amount of "medical products" are consumed without a good scientific basis. The use of parenteral phenytoin, particularly in regard to fosphenytoin sodium, however, is based on good, sound scientific principles.
Labiner DM. Data vs Opinion, Phenytoin vs Fosphenytoin: The Saga Continues. Arch Intern Med. 1999;159(22):2631–2632. doi:10-1001/pubs.Arch Intern Med.-ISSN-0003-9926-159-22-ied90008
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