Rhabdomyolysis is commonly encountered in the hospital; however, national estimates on the incidence of rhabdomyolysis are not available. While patients with highly elevated creatine phosphokinase (CPK) concentrations are generally closely monitored, it is often less clear how to best handle patients with moderate CPK elevations. Clinicians are usually fixated on these patients’ (repeated) CPK measurements, yet it is likely that other relevant information can help stratify these patients by their likelihoods of experiencing unfavorable outcomes.