Long-term follow-up of randomized trials has demonstrated that incidental exposure of the heart during radiotherapy for breast cancer can increase the subsequent risk of heart disease.1 Radiation-related increases in heart disease risk have subsequently been confirmed,2 and a dose-response relationship for ischemic heart disease based on individual patient information has been developed.3
Taylor C, Darby SC. Ischemic Heart Disease and Breast Cancer Radiotherapy: The Way Forward. JAMA Intern Med. 2014;174(1):160–161. doi:10.1001/jamainternmed.2013.9131
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