[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
Invited Commentary
January 2014

Ischemic Heart Disease and Breast Cancer Radiotherapy: The Way Forward

Author Affiliations
  • 1Clinical Trial Service Unit, University of Oxford, Oxford, England
JAMA Intern Med. 2014;174(1):160-161. doi:10.1001/jamainternmed.2013.9131

Long-term follow-up of randomized trials has demonstrated that incidental exposure of the heart during radiotherapy for breast cancer can increase the subsequent risk of heart disease.1 Radiation-related increases in heart disease risk have subsequently been confirmed,2 and a dose-response relationship for ischemic heart disease based on individual patient information has been developed.3