In 1999, I became editor in chief of TheNew England Journal of Medicine (NEJM)—the first woman to head a major medical journal. At the time, the professional staff consisted of 5 full-time deputy editors, 6 part-time associate editors, 3 statistical consultants, and 1 consultant in molecular medicine. All but the last consultant were men. Of the 24 editorial board members, just 3 were women. A few months later, Catherine DeAngelis, MD, became editor in chief of JAMA, a happenstance so surprising that it warranted a front-page article in the Boston Globe (where I was quoted as saying, tongue-in-cheek, “There goes the neighborhood.”).