In Reply While we agree with Dr Ross that software that uses evidence-based or best-practice suggestions could provide diagnostic guidance to physicians, we would like to first recognize the currently established body of work on diagnostic decision support systems that could be leveraged for this purpose. For example, the American Medical Association previously sponsored the dissemination of one of these tools, DXplain,1 and several recent reviews on diagnostic decision-making software highlight opportunities for the field.2 Also, we agree it would be helpful to get more physician professional societies and medical meetings to be inclusive of discussions of these systems, although forums such as the Society to Improve Diagnosis in Medicine (http://www.improvediagnosis.com) and the Diagnostic Error in Medicine annual meetings have recently begun to provide this platform.