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Comment & Response
April 2014

What Constitutes an Adequate Evaluation of Device-Guided Breathing?—Reply

Author Affiliations
  • 1Diabetes Centre, Isala Clinics, Zwolle, the Netherlands
  • 2Department of Internal Medicine, University Medical Center Groningen, Groningen, the Netherlands
  • 3Langerhans Medical Research Group, Zwolle, the Netherlands
JAMA Intern Med. 2014;174(4):638. doi:10.1001/jamainternmed.2013.13790

In Reply We want to thank Huang and Subak for their interest in our study.1 They state that we should not have made strong conclusions concerning nonefficacy based on results extending outside the present study and that we performed an underpowered study with methodological limitations and unsuccessful randomization. We respectfully disagree with all their statements.

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