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July 2014

The Role of Testing for BRCA1 and BRCA2 Mutations in Cancer Prevention

Author Affiliations
  • 1Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts
JAMA Intern Med. 2014;174(7):1023-1024. doi:10.1001/jamainternmed.2014.1322

In May 2013, Angelina Jolie,1 the actress and director, announced in an op-ed in the New York Times that she carried a BRCA1 mutation and had had a preventive double mastectomy. Jolie’s message was striking—by identifying a mutation in a cancer susceptibility gene, one of the most famous actresses of our generation dramatically reduced her risk of dying from cancer.