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Invited Commentary
October 2014

Improving Safety of Diabetes Mellitus Management

Author Affiliations
  • 1Section of Endocrinology, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut
JAMA Intern Med. 2014;174(10):1612-1613. doi:10.1001/jamainternmed.2014.3290

Older adults experience adverse drug events (ADEs) far more often than younger persons. The reasons for this include age-related decline in kidney and liver function, comorbidities, and the use of multiple medications. Oral glucose-lowering agents and insulin are implicated in one-quarter of emergency hospitalizations for ADEs among older US adults.1 Nearly all of these diabetes mellitus (DM)-related drug events are for hypoglycemia. Among oral agents, sulfonylureas lead to most hospital visits for hypoglycemia.