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Editor's Correspondence
January 12, 1998

Asymptomatic Mitral and Aortic Valve Disease Is Seen in Half of the Patients Taking ‘Phen-Fen'

Author Affiliations

Copyright 1998 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.1998

Arch Intern Med. 1998;158(1):102. doi:

The combination of phentermine hydrochloride and fenfluramine hydrochloride, known as phen-fen, has been widely used for the treatment of exogenous obesity.1 The therapy has been highly successful. Up to 10 million obese people have been treated, reversing the trend in recent years toward increasing obesity in the US population. In 1996, the Food and Drug Administration approved dexfenfluramine hydrochloride for long-term monotherapy for obesity.

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