Since its introduction, ketorolac tromethamine (Toradol, Wyeth Laboratories Inc, Philadelphia, Pa) has been extensively used as a potent nonsteroidal anti-inflammatory, analgesic, and antipyretic drug. Pancreatitis is not a recognized complication of the use of ketorolac tromethamine, our MEDLINE search revealing no case reports of acute pancreatitis attributed to the use of ketorolac tromethamine. We describe a middle-aged woman who developed acute pancreatitis after administration of parenteral ketorolac tromethamine.