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Editor's Correspondence
February 23, 1998

Troglitazone: Monotherapy Indication

Arch Intern Med. 1998;158(4):412. doi:

In reply

Lisi's points about the 2 newly approved indications for the use of troglitazone and the role heterogeneity has on the effects of β-adrenergic blocking agents on serum lipoprotein levels are well taken. It must be noted that the latter concept is based on limited data and that the adverse effects of β-adrenergic blocking agents on lipoprotein fractions may be only ameliorated and not completely prevented by substituting agents with intrinsic sympathomimetic activity.1,2 It is true that use of a combined α- and β-adrenergic blocking agent tends to be associated with neutral lipid effects; however, decreases in high-density lipoprotein cholesterol levels have frequently been reported.3-5

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