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Editor's Correspondence
June 22, 1998

Sublingual Nifedipine–Induced Anaphylaxis

Arch Intern Med. 1998;158(12):1378-1379. doi:

Nifedipine therapy administered sublingually or swallowed during treatment of hypertensive emergencies and pseudoemergencies has been widely used in the last decade. Severe adverse effects including symptomatic hypotension,1 stroke,2 ST-segment depression, ventricular fibrillation,3 and myocardial infarction have been reported.4 We describe herein a patient who developed anaphylaxis after receiving sublingual nifedipine for pseudoemergency hypertensive treatment.