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Editor's Correspondence
October 12, 1998

Liver Failure and Peripheral Facial Paralysis in a Case of Primary Amyloidosis

Arch Intern Med. 1998;158(18):2066-2067. doi:

Amyloidosis (AL) is a deposition disease of particular interest for internists given the variety of organs that are involved and the difficulty of the diagnosis. The deposition of slight chains of immunoglobulins in primary AL, similar to the deposit of amyloid protein in secondary AL, may affect any organ. Nevertheless, in primary AL there is a higher incidence of symptoms related to the heart, skin, lungs, and joints. The peripheral nervous system is also commonly affected in both types of AL, although the cranial nerves are rarely involved.1,2 We hereby report the case of a patient with AL in whom, in addition to the usual signs (cardiac, renal, and cutaneous), there was also peripheral facial paralysis and an intrahepatic cholestasis that developed into fatal liver failure.

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