The Advantages of Using Non–HDL-C in the Diagnosis and Treatment of Dyslipidemia—Reply

In reply

We thank Dr Levitt for his letter regarding our recent article.¹ Using the same study population and analytical methods, we performed additional analyses to examine the predictive value of the TC to HDL-C (TC:HDL-C) ratio for CVD mortality. We found that there was a strong positive association between the TC:HDL-C ratio and CVD mortality. When analyzed as continuous variables, the TC:HDL-C ratio was a somewhat poorer predictor than non–HDL-C level in men (χ² = 17.0 and 24.3 for the TC:HDL-C ratio and non–HDL-C level, respectively). In women, the TC:HDL-C ratio was a somewhat better predictor than non–HDL-C level (χ² = 10.9 and 8.3 for the TC:HDL-C ratio and non–HDL-C level, respectively).