Efavirenz is a nonnucleoside reverse transcriptase inhibitor with a potent inhibitory activity against human immunodeficiency virus (HIV), which has been confirmed in clinical trials. The most frequent adverse effects of efavirenz have been symptoms related to the central nervous system, such as dizziness, impaired concentration, insomnia, abnormal dreaming, and maculopapular rash.1 In addition, other adverse skin reactions, such as hypersensitivity syndrome and photosensitivity reaction, have been attributed to efavirenz use.2
Domingo P, Barceló M. Efavirenz-Induced Leukocytoclastic Vasculitis. Arch Intern Med. 2002;162(3):355–356. doi:
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