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Editor's Correspondence
October 14, 2002

Hereditary Angioedema and Hormones

Arch Intern Med. 2002;162(18):2142. doi:

We read with interest the scholarly review on hereditary angioedema by Nzeako et al.1 However, the authors do not mention the association of Turner syndrome with angioedema. Fletcher and Weetman2 have reported a patient with Turner syndrome and hereditary type II angioedema. She had marked worsening of angioedema attacks when she received estrogen replacement to attain necessary physiologic levels. Therefore, estrogen treatment, even at physiologic replacement doses, worsens attacks of hereditary angioedema in estrogen-deficient patients. Also, attacks of angioedema may be precipitated by hypogonadism or antiandrogen treatment.3

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